Letter to the Editor Regarding the “Effectiveness of 190 μg Fluocinolone Acetonide and 700 μg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis” Article [Letter]

Kasserine Taylor,1 Michael W Stewart2 1Department of Ophthalmology, Mayo Clinic Florida, Jacksonville, FL, USA; 2Cornell University, Ithaca, NY, USACorrespondence: Michael W StewartDepartment of Ophthalmology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32250, USATel +1 904-953-2232Fa...

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Autores principales:	Taylor K, Stewart MW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	dexamethasone fluocinolone diabetic macular edema Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/de892c268f4e4fc78b37ad64d2c6831c
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spelling	oai:doaj.org-article:de892c268f4e4fc78b37ad64d2c6831c2021-12-02T12:46:53ZLetter to the Editor Regarding the “Effectiveness of 190 μg Fluocinolone Acetonide and 700 μg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis” Article [Letter]1177-5483https://doaj.org/article/de892c268f4e4fc78b37ad64d2c6831c2020-11-01T00:00:00Zhttps://www.dovepress.com/letter-to-the-editor-regarding-the-ldquoeffectiveness-of-190-mug-fluoc-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kasserine Taylor,1 Michael W Stewart2 1Department of Ophthalmology, Mayo Clinic Florida, Jacksonville, FL, USA; 2Cornell University, Ithaca, NY, USACorrespondence: Michael W StewartDepartment of Ophthalmology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32250, USATel +1 904-953-2232Fax +1 904-953-7040Email stewart.michael@mayo.edu In a recent edition of Clinical Ophthalmology, Zarranz-Ventura and Mali presented1 an area-under-the-curve (AUC) analysis that directly compared the best corrected visual acuity (BCVA) improvements in the  pivotal diabetic macular edema (DME) trials (FAME and MEAD) for the fluocinolone acetonide implant (Iluvien) and the dexamethasone implant (Ozurdex). They concluded that patients in FAME had superior BCVA improvement over the course of 36 months. We contend that this analysis and the resultant conclusions are flawed because of methodologic deficiencies in the MEAD trial.   View the original paper by Zarranz-Ventura and MaliTaylor KStewart MWDove Medical Pressarticledexamethasone fluocinolone diabetic macular edemaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3811-3812 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	dexamethasone fluocinolone diabetic macular edema Ophthalmology RE1-994
spellingShingle	dexamethasone fluocinolone diabetic macular edema Ophthalmology RE1-994 Taylor K Stewart MW Letter to the Editor Regarding the “Effectiveness of 190 μg Fluocinolone Acetonide and 700 μg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis” Article [Letter]
description	Kasserine Taylor,1 Michael W Stewart2 1Department of Ophthalmology, Mayo Clinic Florida, Jacksonville, FL, USA; 2Cornell University, Ithaca, NY, USACorrespondence: Michael W StewartDepartment of Ophthalmology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL 32250, USATel +1 904-953-2232Fax +1 904-953-7040Email stewart.michael@mayo.edu In a recent edition of Clinical Ophthalmology, Zarranz-Ventura and Mali presented1 an area-under-the-curve (AUC) analysis that directly compared the best corrected visual acuity (BCVA) improvements in the  pivotal diabetic macular edema (DME) trials (FAME and MEAD) for the fluocinolone acetonide implant (Iluvien) and the dexamethasone implant (Ozurdex). They concluded that patients in FAME had superior BCVA improvement over the course of 36 months. We contend that this analysis and the resultant conclusions are flawed because of methodologic deficiencies in the MEAD trial.   View the original paper by Zarranz-Ventura and Mali
format	article
author	Taylor K Stewart MW
author_facet	Taylor K Stewart MW
author_sort	Taylor K
title	Letter to the Editor Regarding the “Effectiveness of 190 μg Fluocinolone Acetonide and 700 μg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis” Article [Letter]
title_short	Letter to the Editor Regarding the “Effectiveness of 190 μg Fluocinolone Acetonide and 700 μg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis” Article [Letter]
title_full	Letter to the Editor Regarding the “Effectiveness of 190 μg Fluocinolone Acetonide and 700 μg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis” Article [Letter]
title_fullStr	Letter to the Editor Regarding the “Effectiveness of 190 μg Fluocinolone Acetonide and 700 μg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis” Article [Letter]
title_full_unstemmed	Letter to the Editor Regarding the “Effectiveness of 190 μg Fluocinolone Acetonide and 700 μg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis” Article [Letter]
title_sort	letter to the editor regarding the “effectiveness of 190 μg fluocinolone acetonide and 700 μg dexamethasone intravitreal implants in diabetic macular edema using the area-under-the-curve method: the constant analysis” article [letter]
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/de892c268f4e4fc78b37ad64d2c6831c
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Letter to the Editor Regarding the &ldquo;Effectiveness of 190 &mu;g Fluocinolone Acetonide and 700 &mu;g Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis&rdquo; Article [Letter]

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Letter to the Editor Regarding the “Effectiveness of 190 μg Fluocinolone Acetonide and 700 μg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis” Article [Letter]