Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration

Suofu Qin, Gerard A RodriguesRetinal Disease Research, Department of Biological Sciences, Allergan, Inc., Irvine, CA, USAAbstract: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The etiology of AMD remains poorly understood and no treatment is curren...

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Autores principales:	Suofu Qin, Gerard A Rodrigues
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/de8d80e301fe4178ae6576414fd17ccf
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spelling	oai:doaj.org-article:de8d80e301fe4178ae6576414fd17ccf2021-12-02T01:14:08ZProgress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration1178-7031https://doaj.org/article/de8d80e301fe4178ae6576414fd17ccf2008-12-01T00:00:00Zhttp://www.dovepress.com/progress-and-perspectives-on-the-role-of-rpe-cell-inflammatory-respons-a2661https://doaj.org/toc/1178-7031Suofu Qin, Gerard A RodriguesRetinal Disease Research, Department of Biological Sciences, Allergan, Inc., Irvine, CA, USAAbstract: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The etiology of AMD remains poorly understood and no treatment is currently available for the atrophic form of AMD. Atrophic AMD has been proposed to involve abnormalities of the retinal pigment epithelium (RPE), which lies beneath the photoreceptor cells and normally provides critical metabolic support to these light-sensing cells. Cumulative oxidative stress and local inflammation are thought to represent pathological processes involved in the etiology of atrophic AMD. Studies of tissue culture and animal models reveal that oxidative stress-induced injury to the RPE results in a chronic inflammatory response, drusen formation, and RPE atrophy. RPE degeneration in turn causes a progressive degeneration of photoreceptors, leading to the irreversible loss of vision. This review describes some of the potential major molecular and cellular events contributing to RPE death and inflammatory responses. In addition, potential target areas for therapeutic intervention will be discussed and new experimental therapeutic strategies for atrophic AMD will be presented.Keywords: age-related macular degeneration, danger signals, complement, inflammation, retinal pigment epithelial cells Suofu QinGerard A RodriguesDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2008, Iss default, Pp 49-65 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Suofu Qin Gerard A Rodrigues Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration
description	Suofu Qin, Gerard A RodriguesRetinal Disease Research, Department of Biological Sciences, Allergan, Inc., Irvine, CA, USAAbstract: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The etiology of AMD remains poorly understood and no treatment is currently available for the atrophic form of AMD. Atrophic AMD has been proposed to involve abnormalities of the retinal pigment epithelium (RPE), which lies beneath the photoreceptor cells and normally provides critical metabolic support to these light-sensing cells. Cumulative oxidative stress and local inflammation are thought to represent pathological processes involved in the etiology of atrophic AMD. Studies of tissue culture and animal models reveal that oxidative stress-induced injury to the RPE results in a chronic inflammatory response, drusen formation, and RPE atrophy. RPE degeneration in turn causes a progressive degeneration of photoreceptors, leading to the irreversible loss of vision. This review describes some of the potential major molecular and cellular events contributing to RPE death and inflammatory responses. In addition, potential target areas for therapeutic intervention will be discussed and new experimental therapeutic strategies for atrophic AMD will be presented.Keywords: age-related macular degeneration, danger signals, complement, inflammation, retinal pigment epithelial cells
format	article
author	Suofu Qin Gerard A Rodrigues
author_facet	Suofu Qin Gerard A Rodrigues
author_sort	Suofu Qin
title	Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration
title_short	Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration
title_full	Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration
title_fullStr	Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration
title_full_unstemmed	Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration
title_sort	progress and perspectives on the role of rpe cell inflammatory responses in the development of age-related macular degeneration
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/de8d80e301fe4178ae6576414fd17ccf
work_keys_str_mv	AT suofuqin progressandperspectivesontheroleofrpecellinflammatoryresponsesinthedevelopmentofagerelatedmaculardegeneration AT gerardarodrigues progressandperspectivesontheroleofrpecellinflammatoryresponsesinthedevelopmentofagerelatedmaculardegeneration
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Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration

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