SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression

Enhancers shape gene expression patterns and are involved in disease pathogenesis. Here the authors demonstrate a strategy to screen functional regulatory elements for non-coding RNAs ― illustrated with miR-146a ― and link autoimmune disease risk genetic variants to autoimmune disease etiology.

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Autores principales:	Guojun Hou, Isaac T. W. Harley, Xiaoming Lu, Tian Zhou, Ning Xu, Chao Yao, Yuting Qin, Ye Ouyang, Jianyang Ma, Xinyi Zhu, Xiang Yu, Hong Xu, Dai Dai, Huihua Ding, Zhihua Yin, Zhizhong Ye, Jun Deng, Mi Zhou, Yuanjia Tang, Bahram Namjou, Ya Guo, Matthew T. Weirauch, Leah C. Kottyan, John B. Harley, Nan Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de8dfa40a050458585327f2085f7931f
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spelling	oai:doaj.org-article:de8dfa40a050458585327f2085f7931f2021-12-02T11:56:18ZSLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression10.1038/s41467-020-20460-12041-1723https://doaj.org/article/de8dfa40a050458585327f2085f7931f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20460-1https://doaj.org/toc/2041-1723Enhancers shape gene expression patterns and are involved in disease pathogenesis. Here the authors demonstrate a strategy to screen functional regulatory elements for non-coding RNAs ― illustrated with miR-146a ― and link autoimmune disease risk genetic variants to autoimmune disease etiology.Guojun HouIsaac T. W. HarleyXiaoming LuTian ZhouNing XuChao YaoYuting QinYe OuyangJianyang MaXinyi ZhuXiang YuHong XuDai DaiHuihua DingZhihua YinZhizhong YeJun DengMi ZhouYuanjia TangBahram NamjouYa GuoMatthew T. WeirauchLeah C. KottyanJohn B. HarleyNan ShenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guojun Hou Isaac T. W. Harley Xiaoming Lu Tian Zhou Ning Xu Chao Yao Yuting Qin Ye Ouyang Jianyang Ma Xinyi Zhu Xiang Yu Hong Xu Dai Dai Huihua Ding Zhihua Yin Zhizhong Ye Jun Deng Mi Zhou Yuanjia Tang Bahram Namjou Ya Guo Matthew T. Weirauch Leah C. Kottyan John B. Harley Nan Shen SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression
description	Enhancers shape gene expression patterns and are involved in disease pathogenesis. Here the authors demonstrate a strategy to screen functional regulatory elements for non-coding RNAs ― illustrated with miR-146a ― and link autoimmune disease risk genetic variants to autoimmune disease etiology.
format	article
author	Guojun Hou Isaac T. W. Harley Xiaoming Lu Tian Zhou Ning Xu Chao Yao Yuting Qin Ye Ouyang Jianyang Ma Xinyi Zhu Xiang Yu Hong Xu Dai Dai Huihua Ding Zhihua Yin Zhizhong Ye Jun Deng Mi Zhou Yuanjia Tang Bahram Namjou Ya Guo Matthew T. Weirauch Leah C. Kottyan John B. Harley Nan Shen
author_facet	Guojun Hou Isaac T. W. Harley Xiaoming Lu Tian Zhou Ning Xu Chao Yao Yuting Qin Ye Ouyang Jianyang Ma Xinyi Zhu Xiang Yu Hong Xu Dai Dai Huihua Ding Zhihua Yin Zhizhong Ye Jun Deng Mi Zhou Yuanjia Tang Bahram Namjou Ya Guo Matthew T. Weirauch Leah C. Kottyan John B. Harley Nan Shen
author_sort	Guojun Hou
title	SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression
title_short	SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression
title_full	SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression
title_fullStr	SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression
title_full_unstemmed	SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression
title_sort	sle non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microrna expression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de8dfa40a050458585327f2085f7931f
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SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression

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