Cell reprogramming shapes the mitochondrial DNA landscape

Here the authors describe high depth mitochondrial DNA (mtDNA) sequence analysis of 146 human induced pluripotent stem cell (hiPSC) lines as well as single cell RNA-seq (scRNAseq) of hiPSCs undergoing differentiation from 125 donors; reporting mtDNA diversity and some variants favoured after reprogr...

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Detalles Bibliográficos
Autores principales:	Wei Wei, Daniel J. Gaffney, Patrick F. Chinnery
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de9150da104840bfa505f18f493c528d
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id	oai:doaj.org-article:de9150da104840bfa505f18f493c528d
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spelling	oai:doaj.org-article:de9150da104840bfa505f18f493c528d2021-12-02T16:38:26ZCell reprogramming shapes the mitochondrial DNA landscape10.1038/s41467-021-25482-x2041-1723https://doaj.org/article/de9150da104840bfa505f18f493c528d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25482-xhttps://doaj.org/toc/2041-1723Here the authors describe high depth mitochondrial DNA (mtDNA) sequence analysis of 146 human induced pluripotent stem cell (hiPSC) lines as well as single cell RNA-seq (scRNAseq) of hiPSCs undergoing differentiation from 125 donors; reporting mtDNA diversity and some variants favoured after reprogramming.Wei WeiDaniel J. GaffneyPatrick F. ChinneryNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Wei Daniel J. Gaffney Patrick F. Chinnery Cell reprogramming shapes the mitochondrial DNA landscape
description	Here the authors describe high depth mitochondrial DNA (mtDNA) sequence analysis of 146 human induced pluripotent stem cell (hiPSC) lines as well as single cell RNA-seq (scRNAseq) of hiPSCs undergoing differentiation from 125 donors; reporting mtDNA diversity and some variants favoured after reprogramming.
format	article
author	Wei Wei Daniel J. Gaffney Patrick F. Chinnery
author_facet	Wei Wei Daniel J. Gaffney Patrick F. Chinnery
author_sort	Wei Wei
title	Cell reprogramming shapes the mitochondrial DNA landscape
title_short	Cell reprogramming shapes the mitochondrial DNA landscape
title_full	Cell reprogramming shapes the mitochondrial DNA landscape
title_fullStr	Cell reprogramming shapes the mitochondrial DNA landscape
title_full_unstemmed	Cell reprogramming shapes the mitochondrial DNA landscape
title_sort	cell reprogramming shapes the mitochondrial dna landscape
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/de9150da104840bfa505f18f493c528d
work_keys_str_mv	AT weiwei cellreprogrammingshapesthemitochondrialdnalandscape AT danieljgaffney cellreprogrammingshapesthemitochondrialdnalandscape AT patrickfchinnery cellreprogrammingshapesthemitochondrialdnalandscape
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Cell reprogramming shapes the mitochondrial DNA landscape

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