Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy

Cancer immunotherapy strategies leveraging the body’s own immune system against cancer cells have gained significant attention due to their remarkable therapeutic efficacy. Several immune therapies have been approved for clinical use while expanding the modalities of cancer therapy. However, they ar...

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Autores principales:	Adityanarayan Mohapatra, Padmanaban Sathiyamoorthy, In-Kyu Park
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer immunotherapy metallic nanoparticle tumor microenvironment modulation immune cell regulation antitumor immune response Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/de91988d501a45d093599ffce2aec2cd
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spelling	oai:doaj.org-article:de91988d501a45d093599ffce2aec2cd2021-11-25T18:41:17ZMetallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy10.3390/pharmaceutics131118671999-4923https://doaj.org/article/de91988d501a45d093599ffce2aec2cd2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1867https://doaj.org/toc/1999-4923Cancer immunotherapy strategies leveraging the body’s own immune system against cancer cells have gained significant attention due to their remarkable therapeutic efficacy. Several immune therapies have been approved for clinical use while expanding the modalities of cancer therapy. However, they are still not effective in a broad range of cancer patients because of the typical immunosuppressive microenvironment and limited antitumor immunity achieved with the current treatment. Novel approaches, such as nanoparticle-mediated cancer immunotherapies, are being developed to overcome these challenges. Various types of nanoparticles, including liposomal, polymeric, and metallic nanoparticles, are reported for the development of effective cancer therapeutics. Metallic nanoparticles (MNPs) are one of the promising candidates for anticancer therapy due to their unique theranostic properties and are thus explored as both imaging and therapeutic agents. In addition, MNPs offer a dense surface functionalization to target tumor tissue and deliver genetic, therapeutic, and immunomodulatory agents. Furthermore, MNPs interact with the tumor microenvironment (TME) and regulate the levels of tumor hypoxia, glutathione (GSH), and reactive oxygen species (ROS) for remodulation of TME for successful therapy. In this review, we discuss the role of nanoparticles in tumor microenvironment modulation and anticancer therapy. In particular, we evaluated the response of MNP-mediated immune cells, such as dendritic cells, macrophages, T cells and NK cells, against tumor cells and analyzed the role of MNP-based cancer therapies in regulating the immunosuppressive environment.Adityanarayan MohapatraPadmanaban SathiyamoorthyIn-Kyu ParkMDPI AGarticlecancer immunotherapymetallic nanoparticletumor microenvironment modulationimmune cell regulationantitumor immune responsePharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1867, p 1867 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer immunotherapy metallic nanoparticle tumor microenvironment modulation immune cell regulation antitumor immune response Pharmacy and materia medica RS1-441
spellingShingle	cancer immunotherapy metallic nanoparticle tumor microenvironment modulation immune cell regulation antitumor immune response Pharmacy and materia medica RS1-441 Adityanarayan Mohapatra Padmanaban Sathiyamoorthy In-Kyu Park Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy
description	Cancer immunotherapy strategies leveraging the body’s own immune system against cancer cells have gained significant attention due to their remarkable therapeutic efficacy. Several immune therapies have been approved for clinical use while expanding the modalities of cancer therapy. However, they are still not effective in a broad range of cancer patients because of the typical immunosuppressive microenvironment and limited antitumor immunity achieved with the current treatment. Novel approaches, such as nanoparticle-mediated cancer immunotherapies, are being developed to overcome these challenges. Various types of nanoparticles, including liposomal, polymeric, and metallic nanoparticles, are reported for the development of effective cancer therapeutics. Metallic nanoparticles (MNPs) are one of the promising candidates for anticancer therapy due to their unique theranostic properties and are thus explored as both imaging and therapeutic agents. In addition, MNPs offer a dense surface functionalization to target tumor tissue and deliver genetic, therapeutic, and immunomodulatory agents. Furthermore, MNPs interact with the tumor microenvironment (TME) and regulate the levels of tumor hypoxia, glutathione (GSH), and reactive oxygen species (ROS) for remodulation of TME for successful therapy. In this review, we discuss the role of nanoparticles in tumor microenvironment modulation and anticancer therapy. In particular, we evaluated the response of MNP-mediated immune cells, such as dendritic cells, macrophages, T cells and NK cells, against tumor cells and analyzed the role of MNP-based cancer therapies in regulating the immunosuppressive environment.
format	article
author	Adityanarayan Mohapatra Padmanaban Sathiyamoorthy In-Kyu Park
author_facet	Adityanarayan Mohapatra Padmanaban Sathiyamoorthy In-Kyu Park
author_sort	Adityanarayan Mohapatra
title	Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy
title_short	Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy
title_full	Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy
title_fullStr	Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy
title_full_unstemmed	Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy
title_sort	metallic nanoparticle-mediated immune cell regulation and advanced cancer immunotherapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/de91988d501a45d093599ffce2aec2cd
work_keys_str_mv	AT adityanarayanmohapatra metallicnanoparticlemediatedimmunecellregulationandadvancedcancerimmunotherapy AT padmanabansathiyamoorthy metallicnanoparticlemediatedimmunecellregulationandadvancedcancerimmunotherapy AT inkyupark metallicnanoparticlemediatedimmunecellregulationandadvancedcancerimmunotherapy
_version_	1718410804882046976

Metallic Nanoparticle-Mediated Immune Cell Regulation and Advanced Cancer Immunotherapy

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