Tailored Systemic Therapy for Colorectal Cancer Liver Metastases

Liver metastases are the most common site of metastatic spread in colorectal cancer. Current treatment approaches involve effective systemic therapies in combination with surgical and/or interventional strategies. Multimodal strategies greatly improved clinical outcomes of patients with metastatic c...

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Autores principales:	Carolin Czauderna, Kim Luley, Nikolas von Bubnoff, Jens U. Marquardt
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colorectal cancer molecular biomarkers prognosis prediction Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/de919e8f156747908800041d56b6a7c0
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id	oai:doaj.org-article:de919e8f156747908800041d56b6a7c0
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spelling	oai:doaj.org-article:de919e8f156747908800041d56b6a7c02021-11-11T17:13:50ZTailored Systemic Therapy for Colorectal Cancer Liver Metastases10.3390/ijms2221117801422-00671661-6596https://doaj.org/article/de919e8f156747908800041d56b6a7c02021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11780https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Liver metastases are the most common site of metastatic spread in colorectal cancer. Current treatment approaches involve effective systemic therapies in combination with surgical and/or interventional strategies. Multimodal strategies greatly improved clinical outcomes of patients with metastatic colorectal cancer over the last decades. Identification of predictive and prognostic biomarkers helped to comprehensively refine individual targeted treatment approaches and resulted in median overall survival rates of 30 months or longer. Current guidelines, thus, recommend treatment selection according to patients’ performance status, tumor localization and stage as well as the tumor’s molecular and genetic status. Here, we outline the latest developments in molecular decision-making for patients with upfront resectable, potentially or initially unresectable and non/never-resectable colorectal cancer liver metastases.Carolin CzaudernaKim LuleyNikolas von BubnoffJens U. MarquardtMDPI AGarticlecolorectal cancermolecular biomarkersprognosispredictionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11780, p 11780 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer molecular biomarkers prognosis prediction Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	colorectal cancer molecular biomarkers prognosis prediction Biology (General) QH301-705.5 Chemistry QD1-999 Carolin Czauderna Kim Luley Nikolas von Bubnoff Jens U. Marquardt Tailored Systemic Therapy for Colorectal Cancer Liver Metastases
description	Liver metastases are the most common site of metastatic spread in colorectal cancer. Current treatment approaches involve effective systemic therapies in combination with surgical and/or interventional strategies. Multimodal strategies greatly improved clinical outcomes of patients with metastatic colorectal cancer over the last decades. Identification of predictive and prognostic biomarkers helped to comprehensively refine individual targeted treatment approaches and resulted in median overall survival rates of 30 months or longer. Current guidelines, thus, recommend treatment selection according to patients’ performance status, tumor localization and stage as well as the tumor’s molecular and genetic status. Here, we outline the latest developments in molecular decision-making for patients with upfront resectable, potentially or initially unresectable and non/never-resectable colorectal cancer liver metastases.
format	article
author	Carolin Czauderna Kim Luley Nikolas von Bubnoff Jens U. Marquardt
author_facet	Carolin Czauderna Kim Luley Nikolas von Bubnoff Jens U. Marquardt
author_sort	Carolin Czauderna
title	Tailored Systemic Therapy for Colorectal Cancer Liver Metastases
title_short	Tailored Systemic Therapy for Colorectal Cancer Liver Metastases
title_full	Tailored Systemic Therapy for Colorectal Cancer Liver Metastases
title_fullStr	Tailored Systemic Therapy for Colorectal Cancer Liver Metastases
title_full_unstemmed	Tailored Systemic Therapy for Colorectal Cancer Liver Metastases
title_sort	tailored systemic therapy for colorectal cancer liver metastases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/de919e8f156747908800041d56b6a7c0
work_keys_str_mv	AT carolinczauderna tailoredsystemictherapyforcolorectalcancerlivermetastases AT kimluley tailoredsystemictherapyforcolorectalcancerlivermetastases AT nikolasvonbubnoff tailoredsystemictherapyforcolorectalcancerlivermetastases AT jensumarquardt tailoredsystemictherapyforcolorectalcancerlivermetastases
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Tailored Systemic Therapy for Colorectal Cancer Liver Metastases

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