Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides

Traditional synthesis of stereodefined piperidines requires selective installation of functional groups that can lower efficiency and modularity. Here, the authors assemble stereochemically complex and highly substituted dehydropiperidines via an intermolecular ring expansion between bicyclic azirid...

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Autores principales:	Josephine Eshon, Kate A. Nicastri, Steven C. Schmid, William T. Raskopf, Ilia A. Guzei, Israel Fernández, Jennifer M. Schomaker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de9587a8a724479bad12880067f38cb0
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spelling	oai:doaj.org-article:de9587a8a724479bad12880067f38cb02021-12-02T13:35:01ZIntermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides10.1038/s41467-020-15134-x2041-1723https://doaj.org/article/de9587a8a724479bad12880067f38cb02020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15134-xhttps://doaj.org/toc/2041-1723Traditional synthesis of stereodefined piperidines requires selective installation of functional groups that can lower efficiency and modularity. Here, the authors assemble stereochemically complex and highly substituted dehydropiperidines via an intermolecular ring expansion between bicyclic aziridines and Rh-supported vinyl carbenes.Josephine EshonKate A. NicastriSteven C. SchmidWilliam T. RaskopfIlia A. GuzeiIsrael FernándezJennifer M. SchomakerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Josephine Eshon Kate A. Nicastri Steven C. Schmid William T. Raskopf Ilia A. Guzei Israel Fernández Jennifer M. Schomaker Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides
description	Traditional synthesis of stereodefined piperidines requires selective installation of functional groups that can lower efficiency and modularity. Here, the authors assemble stereochemically complex and highly substituted dehydropiperidines via an intermolecular ring expansion between bicyclic aziridines and Rh-supported vinyl carbenes.
format	article
author	Josephine Eshon Kate A. Nicastri Steven C. Schmid William T. Raskopf Ilia A. Guzei Israel Fernández Jennifer M. Schomaker
author_facet	Josephine Eshon Kate A. Nicastri Steven C. Schmid William T. Raskopf Ilia A. Guzei Israel Fernández Jennifer M. Schomaker
author_sort	Josephine Eshon
title	Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides
title_short	Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides
title_full	Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides
title_fullStr	Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides
title_full_unstemmed	Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides
title_sort	intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/de9587a8a724479bad12880067f38cb0
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Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides

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