The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study

Abstract Several commonly used scoring systems (SOFA, SAPS II, LODS, and SIRS) are currently lacking large sample data to confirm the predictive value of 30-day mortality from sepsis, and their clinical net benefits of predicting mortality are still inconclusive. The baseline data, LODS score, SAPS...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Tianyang Hu, Huajie Lv, Youfan Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/de96af84603643968dd8d8e94c3c81d2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:de96af84603643968dd8d8e94c3c81d2
record_format dspace
spelling oai:doaj.org-article:de96af84603643968dd8d8e94c3c81d22021-12-02T16:53:19ZThe association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study10.1038/s41598-021-90806-22045-2322https://doaj.org/article/de96af84603643968dd8d8e94c3c81d22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90806-2https://doaj.org/toc/2045-2322Abstract Several commonly used scoring systems (SOFA, SAPS II, LODS, and SIRS) are currently lacking large sample data to confirm the predictive value of 30-day mortality from sepsis, and their clinical net benefits of predicting mortality are still inconclusive. The baseline data, LODS score, SAPS II score, SIRS score, SOFA score, and 30-day prognosis of patients who met the diagnostic criteria of sepsis were retrieved from the Medical Information Mart for Intensive Care III (MIMIC-III) intensive care unit (ICU) database. Receiver operating characteristic (ROC) curves and comparisons between the areas under the ROC curves (AUC) were conducted. Decision curve analysis (DCA) was performed to determine the net benefits between the four scoring systems and 30-day mortality of sepsis. For all cases in the cohort study, the AUC of LODS, SAPS II, SIRS, SOFA were 0.733, 0.787, 0.597, and 0.688, respectively. The differences between the scoring systems were statistically significant (all P-values < 0.0001), and stratified analyses (the elderly and non-elderly) also showed the superiority of SAPS II among the four systems. According to the DCA, the net benefit ranges in descending order were SAPS II, LODS, SOFA, and SIRS. For stratified analyses of the elderly or non-elderly groups, the results also showed that SAPS II had the most net benefit. Among the four commonly used scoring systems, the SAPS II score has the highest predictive value for 30-day mortality from sepsis, which is better than LODS, SIRS, and SOFA. The results of the DCA curves show that using the SAPS II score to predict the 30-day mortality of intensive care patients with sepsis to guide clinical applications may obtain the highest net benefit.Tianyang HuHuajie LvYoufan JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Tianyang Hu
Huajie Lv
Youfan Jiang
The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
description Abstract Several commonly used scoring systems (SOFA, SAPS II, LODS, and SIRS) are currently lacking large sample data to confirm the predictive value of 30-day mortality from sepsis, and their clinical net benefits of predicting mortality are still inconclusive. The baseline data, LODS score, SAPS II score, SIRS score, SOFA score, and 30-day prognosis of patients who met the diagnostic criteria of sepsis were retrieved from the Medical Information Mart for Intensive Care III (MIMIC-III) intensive care unit (ICU) database. Receiver operating characteristic (ROC) curves and comparisons between the areas under the ROC curves (AUC) were conducted. Decision curve analysis (DCA) was performed to determine the net benefits between the four scoring systems and 30-day mortality of sepsis. For all cases in the cohort study, the AUC of LODS, SAPS II, SIRS, SOFA were 0.733, 0.787, 0.597, and 0.688, respectively. The differences between the scoring systems were statistically significant (all P-values < 0.0001), and stratified analyses (the elderly and non-elderly) also showed the superiority of SAPS II among the four systems. According to the DCA, the net benefit ranges in descending order were SAPS II, LODS, SOFA, and SIRS. For stratified analyses of the elderly or non-elderly groups, the results also showed that SAPS II had the most net benefit. Among the four commonly used scoring systems, the SAPS II score has the highest predictive value for 30-day mortality from sepsis, which is better than LODS, SIRS, and SOFA. The results of the DCA curves show that using the SAPS II score to predict the 30-day mortality of intensive care patients with sepsis to guide clinical applications may obtain the highest net benefit.
format article
author Tianyang Hu
Huajie Lv
Youfan Jiang
author_facet Tianyang Hu
Huajie Lv
Youfan Jiang
author_sort Tianyang Hu
title The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_short The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_full The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_fullStr The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_full_unstemmed The association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
title_sort association between four scoring systems and 30-day mortality among intensive care patients with sepsis: a cohort study
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/de96af84603643968dd8d8e94c3c81d2
work_keys_str_mv AT tianyanghu theassociationbetweenfourscoringsystemsand30daymortalityamongintensivecarepatientswithsepsisacohortstudy
AT huajielv theassociationbetweenfourscoringsystemsand30daymortalityamongintensivecarepatientswithsepsisacohortstudy
AT youfanjiang theassociationbetweenfourscoringsystemsand30daymortalityamongintensivecarepatientswithsepsisacohortstudy
AT tianyanghu associationbetweenfourscoringsystemsand30daymortalityamongintensivecarepatientswithsepsisacohortstudy
AT huajielv associationbetweenfourscoringsystemsand30daymortalityamongintensivecarepatientswithsepsisacohortstudy
AT youfanjiang associationbetweenfourscoringsystemsand30daymortalityamongintensivecarepatientswithsepsisacohortstudy
_version_ 1718382891104206848