Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors

Mitochondrial dynamics regulate critical processes. Here the authors show that genes regulating mitochondrial dynamics are frequently amplified in human cancers, and that these alterations are associated with changes in drug sensitivity including increased sensitivity to the apoptosis-targeting Smac...

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Autores principales:	Grace R. Anderson, Suzanne E. Wardell, Merve Cakir, Catherine Yip, Yeong-ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina A. Chao, Donald P. McDonnell, Kris C. Wood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de9748c806cf4ead9e12f2fd548f0dad
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spelling	oai:doaj.org-article:de9748c806cf4ead9e12f2fd548f0dad2021-12-02T15:34:49ZDysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors10.1038/s41467-018-04033-x2041-1723https://doaj.org/article/de9748c806cf4ead9e12f2fd548f0dad2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04033-xhttps://doaj.org/toc/2041-1723Mitochondrial dynamics regulate critical processes. Here the authors show that genes regulating mitochondrial dynamics are frequently amplified in human cancers, and that these alterations are associated with changes in drug sensitivity including increased sensitivity to the apoptosis-targeting Smac mimetics.Grace R. AndersonSuzanne E. WardellMerve CakirCatherine YipYeong-ran AhnMoiez AliAlexander P. YllanesChristina A. ChaoDonald P. McDonnellKris C. WoodNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Grace R. Anderson Suzanne E. Wardell Merve Cakir Catherine Yip Yeong-ran Ahn Moiez Ali Alexander P. Yllanes Christina A. Chao Donald P. McDonnell Kris C. Wood Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
description	Mitochondrial dynamics regulate critical processes. Here the authors show that genes regulating mitochondrial dynamics are frequently amplified in human cancers, and that these alterations are associated with changes in drug sensitivity including increased sensitivity to the apoptosis-targeting Smac mimetics.
format	article
author	Grace R. Anderson Suzanne E. Wardell Merve Cakir Catherine Yip Yeong-ran Ahn Moiez Ali Alexander P. Yllanes Christina A. Chao Donald P. McDonnell Kris C. Wood
author_facet	Grace R. Anderson Suzanne E. Wardell Merve Cakir Catherine Yip Yeong-ran Ahn Moiez Ali Alexander P. Yllanes Christina A. Chao Donald P. McDonnell Kris C. Wood
author_sort	Grace R. Anderson
title	Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
title_short	Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
title_full	Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
title_fullStr	Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
title_full_unstemmed	Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
title_sort	dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/de9748c806cf4ead9e12f2fd548f0dad
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Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors

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