Depression in people with type 2 diabetes: current perspectives

Lina Darwish,1–4 Erika Beroncal,1–3 Ma Veronica Sison,1–3 Walter Swardfager1–4 1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada; 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; 3Cardiac...

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Autores principales:	Darwish L, Beroncal E, Sison MV, Swardfager W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Type 2 diabetes Depression Mood Complications Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/de97c9c8c5f345e3b2eb5d5481fc29f3
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id	oai:doaj.org-article:de97c9c8c5f345e3b2eb5d5481fc29f3
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spelling	oai:doaj.org-article:de97c9c8c5f345e3b2eb5d5481fc29f32021-12-02T00:48:29ZDepression in people with type 2 diabetes: current perspectives1178-7007https://doaj.org/article/de97c9c8c5f345e3b2eb5d5481fc29f32018-07-01T00:00:00Zhttps://www.dovepress.com/depression-in-people-with-type-2-diabetes-current-perspectives-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lina Darwish,1–4 Erika Beroncal,1–3 Ma Veronica Sison,1–3 Walter Swardfager1–4 1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada; 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; 3Cardiac Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, Toronto, ON, Canada; 4Canadian Partnership for Stroke Recovery, Toronto, ON, Canada Abstract: Type 2 diabetes mellitus (T2DM) is associated with depressive symptoms, and comorbid depression in those with T2DM has been associated with adverse clinical profiles. Recognizing and addressing psychological symptoms remain significant clinical challenges in T2DM. Possible mediators of the reciprocal relationship between T2DM and depression may include physical activity levels, effectiveness of self-management, distress associated with a new T2DM diagnosis, and frailty associated with advanced diabetes duration. The latter considerations contribute to a “J-shaped” trajectory from the time of diagnosis. There remain significant challenges to screening for clinical risks associated with psychological symptoms in T2DM; poorer outcomes may be associated with major depressive episodes, isolated (eg, anhedonic), or subsyndromal depressive symptoms, depressive-like symptoms more specific to T2DM (eg, diabetes-related distress), apathy or fatigue. In this review, we discuss current perspectives on depression in the context of T2DM with implications for screening and management of these highly comorbid conditions. Keywords: type 2 diabetes, depression, mood, complicationsDarwish LBeroncal ESison MVSwardfager WDove Medical PressarticleType 2 diabetesDepressionMoodComplicationsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 333-343 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 diabetes Depression Mood Complications Specialties of internal medicine RC581-951
spellingShingle	Type 2 diabetes Depression Mood Complications Specialties of internal medicine RC581-951 Darwish L Beroncal E Sison MV Swardfager W Depression in people with type 2 diabetes: current perspectives
description	Lina Darwish,1–4 Erika Beroncal,1–3 Ma Veronica Sison,1–3 Walter Swardfager1–4 1Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada; 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; 3Cardiac Rehabilitation Program, University Health Network Toronto Rehabilitation Institute, Toronto, ON, Canada; 4Canadian Partnership for Stroke Recovery, Toronto, ON, Canada Abstract: Type 2 diabetes mellitus (T2DM) is associated with depressive symptoms, and comorbid depression in those with T2DM has been associated with adverse clinical profiles. Recognizing and addressing psychological symptoms remain significant clinical challenges in T2DM. Possible mediators of the reciprocal relationship between T2DM and depression may include physical activity levels, effectiveness of self-management, distress associated with a new T2DM diagnosis, and frailty associated with advanced diabetes duration. The latter considerations contribute to a “J-shaped” trajectory from the time of diagnosis. There remain significant challenges to screening for clinical risks associated with psychological symptoms in T2DM; poorer outcomes may be associated with major depressive episodes, isolated (eg, anhedonic), or subsyndromal depressive symptoms, depressive-like symptoms more specific to T2DM (eg, diabetes-related distress), apathy or fatigue. In this review, we discuss current perspectives on depression in the context of T2DM with implications for screening and management of these highly comorbid conditions. Keywords: type 2 diabetes, depression, mood, complications
format	article
author	Darwish L Beroncal E Sison MV Swardfager W
author_facet	Darwish L Beroncal E Sison MV Swardfager W
author_sort	Darwish L
title	Depression in people with type 2 diabetes: current perspectives
title_short	Depression in people with type 2 diabetes: current perspectives
title_full	Depression in people with type 2 diabetes: current perspectives
title_fullStr	Depression in people with type 2 diabetes: current perspectives
title_full_unstemmed	Depression in people with type 2 diabetes: current perspectives
title_sort	depression in people with type 2 diabetes: current perspectives
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/de97c9c8c5f345e3b2eb5d5481fc29f3
work_keys_str_mv	AT darwishl depressioninpeoplewithtype2diabetescurrentperspectives AT beroncale depressioninpeoplewithtype2diabetescurrentperspectives AT sisonmv depressioninpeoplewithtype2diabetescurrentperspectives AT swardfagerw depressioninpeoplewithtype2diabetescurrentperspectives
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Depression in people with type 2 diabetes: current perspectives

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