Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues

Lactobacillus associates with vaginal protection from HIV-1 infection. Here, the authors show that lactobacilli extracellular vesicles contain bacterial proteins and metabolites that inhibit HIV-1 infection in T cells and in human cervico-vaginal and tonsillar tissues ex vivo via altering viral Env...

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Autores principales: Rogers A. Ñahui Palomino, Christophe Vanpouille, Luca Laghi, Carola Parolin, Kamran Melikov, Peter Backlund, Beatrice Vitali, Leonid Margolis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/de98294add514f1d93ee457111f3c3d0
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Sumario:Lactobacillus associates with vaginal protection from HIV-1 infection. Here, the authors show that lactobacilli extracellular vesicles contain bacterial proteins and metabolites that inhibit HIV-1 infection in T cells and in human cervico-vaginal and tonsillar tissues ex vivo via altering viral Env proteins.