CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors

CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 rec...

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Autores principales:	Linchun Jin, Haipeng Tao, Aida Karachi, Yu Long, Alicia Y. Hou, Meng Na, Kyle A. Dyson, Adam J. Grippin, Loic P. Deleyrolle, Wang Zhang, Didier A. Rajon, Qiong J. Wang, James C. Yang, Jesse L. Kresak, Elias J. Sayour, Maryam Rahman, Frank J. Bova, Zhiguo Lin, Duane A. Mitchell, Jianping Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/de9a908e5e6e46b0b45bc79a9225470e
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spelling	oai:doaj.org-article:de9a908e5e6e46b0b45bc79a9225470e2021-12-02T14:38:47ZCXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors10.1038/s41467-019-11869-42041-1723https://doaj.org/article/de9a908e5e6e46b0b45bc79a9225470e2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11869-4https://doaj.org/toc/2041-1723CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 receptors that mediate their migration into the tumor microenvironment when IL-8 production in tumor is naturally expressed or enhanced by radiation.Linchun JinHaipeng TaoAida KarachiYu LongAlicia Y. HouMeng NaKyle A. DysonAdam J. GrippinLoic P. DeleyrolleWang ZhangDidier A. RajonQiong J. WangJames C. YangJesse L. KresakElias J. SayourMaryam RahmanFrank J. BovaZhiguo LinDuane A. MitchellJianping HuangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linchun Jin Haipeng Tao Aida Karachi Yu Long Alicia Y. Hou Meng Na Kyle A. Dyson Adam J. Grippin Loic P. Deleyrolle Wang Zhang Didier A. Rajon Qiong J. Wang James C. Yang Jesse L. Kresak Elias J. Sayour Maryam Rahman Frank J. Bova Zhiguo Lin Duane A. Mitchell Jianping Huang CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
description	CAR T-cell therapy efficacy in solid tumors is limited by inadequate T-cell migration and/or persistence in tumour microenvironment. Here, the authors show that the activity of tumour-antigen specific CAR T cells, in multiple preclinical mouse models, can be enhanced by co-expression of two IL-8 receptors that mediate their migration into the tumor microenvironment when IL-8 production in tumor is naturally expressed or enhanced by radiation.
format	article
author	Linchun Jin Haipeng Tao Aida Karachi Yu Long Alicia Y. Hou Meng Na Kyle A. Dyson Adam J. Grippin Loic P. Deleyrolle Wang Zhang Didier A. Rajon Qiong J. Wang James C. Yang Jesse L. Kresak Elias J. Sayour Maryam Rahman Frank J. Bova Zhiguo Lin Duane A. Mitchell Jianping Huang
author_facet	Linchun Jin Haipeng Tao Aida Karachi Yu Long Alicia Y. Hou Meng Na Kyle A. Dyson Adam J. Grippin Loic P. Deleyrolle Wang Zhang Didier A. Rajon Qiong J. Wang James C. Yang Jesse L. Kresak Elias J. Sayour Maryam Rahman Frank J. Bova Zhiguo Lin Duane A. Mitchell Jianping Huang
author_sort	Linchun Jin
title	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_short	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_full	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_fullStr	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_full_unstemmed	CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
title_sort	cxcr1- or cxcr2-modified car t cells co-opt il-8 for maximal antitumor efficacy in solid tumors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/de9a908e5e6e46b0b45bc79a9225470e
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CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors

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