Animal models of systemic sclerosis: their utility and limitations

Carol M Artlett Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Without doubt, animal models have provided significant insights into our understanding of the rheumatological diseases; however, no model has accurately replicated all...

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Autor principal:	Artlett CM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/dea1b0eb25bf4db99e7cfe76f68642e4
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spelling	oai:doaj.org-article:dea1b0eb25bf4db99e7cfe76f68642e42021-12-02T05:11:08ZAnimal models of systemic sclerosis: their utility and limitations1179-156Xhttps://doaj.org/article/dea1b0eb25bf4db99e7cfe76f68642e42014-07-01T00:00:00Zhttp://www.dovepress.com/animal-models-of-systemic-sclerosis-their-utility-and-limitations-a17438https://doaj.org/toc/1179-156X Carol M Artlett Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Without doubt, animal models have provided significant insights into our understanding of the rheumatological diseases; however, no model has accurately replicated all aspects of any autoimmune disease. Recent years have seen a plethora of knockouts and transgenics that have contributed to our knowledge of the initiating events of systemic sclerosis, an autoimmune disease. In this review, the focus is on models of systemic sclerosis and how they have progressed our understanding of fibrosis and vasculopathy, and whether they are relevant to the pathogenesis of systemic sclerosis. Keywords: systemic sclerosis, animal models, vasculopathy, fibrosis, chicken, mouseArtlett CMDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2014, Iss default, Pp 65-81 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Artlett CM Animal models of systemic sclerosis: their utility and limitations
description	Carol M Artlett Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA Abstract: Without doubt, animal models have provided significant insights into our understanding of the rheumatological diseases; however, no model has accurately replicated all aspects of any autoimmune disease. Recent years have seen a plethora of knockouts and transgenics that have contributed to our knowledge of the initiating events of systemic sclerosis, an autoimmune disease. In this review, the focus is on models of systemic sclerosis and how they have progressed our understanding of fibrosis and vasculopathy, and whether they are relevant to the pathogenesis of systemic sclerosis. Keywords: systemic sclerosis, animal models, vasculopathy, fibrosis, chicken, mouse
format	article
author	Artlett CM
author_facet	Artlett CM
author_sort	Artlett CM
title	Animal models of systemic sclerosis: their utility and limitations
title_short	Animal models of systemic sclerosis: their utility and limitations
title_full	Animal models of systemic sclerosis: their utility and limitations
title_fullStr	Animal models of systemic sclerosis: their utility and limitations
title_full_unstemmed	Animal models of systemic sclerosis: their utility and limitations
title_sort	animal models of systemic sclerosis: their utility and limitations
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/dea1b0eb25bf4db99e7cfe76f68642e4
work_keys_str_mv	AT artlettcm animalmodelsofsystemicsclerosistheirutilityandlimitations
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Animal models of systemic sclerosis: their utility and limitations

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