Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds

Inflammation is the primary biological reaction to induce severe infection or injury in the immune system. Control of different inflammatory cytokines, such as nitric oxide (NO), interleukins (IL), tumor necrosis factor alpha-(TNF-α), noncytokine mediator, prostaglandin E2 (PGE2), mitogen activated...

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Autores principales:	Thanasekaran Jayakumar, Joen-Rong Sheu, Chih-Wei Hsia, Periyakali Saravana Bhavan, Chao-Chien Chang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ruthenium compounds anti-inflammatory effects MAPKs NF-κB inflammatory cytokines ROS Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/dea28a0aefa949f5ae81a6985c99c4ce
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spelling	oai:doaj.org-article:dea28a0aefa949f5ae81a6985c99c4ce2021-11-11T15:09:39ZAnti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds10.3390/app1121100922076-3417https://doaj.org/article/dea28a0aefa949f5ae81a6985c99c4ce2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/10092https://doaj.org/toc/2076-3417Inflammation is the primary biological reaction to induce severe infection or injury in the immune system. Control of different inflammatory cytokines, such as nitric oxide (NO), interleukins (IL), tumor necrosis factor alpha-(TNF-α), noncytokine mediator, prostaglandin E2 (PGE2), mitogen activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB), facilitates anti-inflammatory effect of different substances. Coordination metal complexes have been applied as metallo-drugs. Several metal complexes have found to possess potent biological activities, especially anticancer, cardioprotective, chondroprotective and anti-parasitosis activities. Among the metallo drugs, ruthenium-based (Ru) complexes have paid much attention in clinical applications. Despite the kinetic nature of Ru complexes is similar to platinum in terms of cell division events, their toxic effect is lower than that of cisplatin. This paper reviews the anti-inflammatory effect of novel synthetic Ru complexes with potential molecular mechanisms that are actively involved.Thanasekaran JayakumarJoen-Rong SheuChih-Wei HsiaPeriyakali Saravana BhavanChao-Chien ChangMDPI AGarticleruthenium compoundsanti-inflammatory effectsMAPKsNF-κBinflammatory cytokinesROSTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10092, p 10092 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ruthenium compounds anti-inflammatory effects MAPKs NF-κB inflammatory cytokines ROS Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	ruthenium compounds anti-inflammatory effects MAPKs NF-κB inflammatory cytokines ROS Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Thanasekaran Jayakumar Joen-Rong Sheu Chih-Wei Hsia Periyakali Saravana Bhavan Chao-Chien Chang Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds
description	Inflammation is the primary biological reaction to induce severe infection or injury in the immune system. Control of different inflammatory cytokines, such as nitric oxide (NO), interleukins (IL), tumor necrosis factor alpha-(TNF-α), noncytokine mediator, prostaglandin E2 (PGE2), mitogen activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB), facilitates anti-inflammatory effect of different substances. Coordination metal complexes have been applied as metallo-drugs. Several metal complexes have found to possess potent biological activities, especially anticancer, cardioprotective, chondroprotective and anti-parasitosis activities. Among the metallo drugs, ruthenium-based (Ru) complexes have paid much attention in clinical applications. Despite the kinetic nature of Ru complexes is similar to platinum in terms of cell division events, their toxic effect is lower than that of cisplatin. This paper reviews the anti-inflammatory effect of novel synthetic Ru complexes with potential molecular mechanisms that are actively involved.
format	article
author	Thanasekaran Jayakumar Joen-Rong Sheu Chih-Wei Hsia Periyakali Saravana Bhavan Chao-Chien Chang
author_facet	Thanasekaran Jayakumar Joen-Rong Sheu Chih-Wei Hsia Periyakali Saravana Bhavan Chao-Chien Chang
author_sort	Thanasekaran Jayakumar
title	Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds
title_short	Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds
title_full	Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds
title_fullStr	Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds
title_full_unstemmed	Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds
title_sort	anti-inflammatory mechanisms of novel synthetic ruthenium compounds
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/dea28a0aefa949f5ae81a6985c99c4ce
work_keys_str_mv	AT thanasekaranjayakumar antiinflammatorymechanismsofnovelsyntheticrutheniumcompounds AT joenrongsheu antiinflammatorymechanismsofnovelsyntheticrutheniumcompounds AT chihweihsia antiinflammatorymechanismsofnovelsyntheticrutheniumcompounds AT periyakalisaravanabhavan antiinflammatorymechanismsofnovelsyntheticrutheniumcompounds AT chaochienchang antiinflammatorymechanismsofnovelsyntheticrutheniumcompounds
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Anti-Inflammatory Mechanisms of Novel Synthetic Ruthenium Compounds

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