Pathogenic D76N Variant of β<sub>2</sub>-Microglobulin: Synergy of Diverse Effects in Both the Native and Amyloid States

β<sub>2</sub>-microglobulin (β2m), the light chain of the MHC-I complex, is associated with dialysis-related amyloidosis (DRA). Recently, a hereditary systemic amyloidosis was discovered, caused by a naturally occurring D76N β2m variant, which showed a structure remarkably similar to the...

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Main Authors:	Éva Bulyáki, Judit Kun, Tamás Molnár, Alexandra Papp, András Micsonai, Henrietta Vadászi, Borbála Márialigeti, Attila István Kovács, Gabriella Gellén, Keiichi Yamaguchi, Yuxi Lin, Masatomo So, Mihály Józsi, Gitta Schlosser, Young-Ho Lee, Károly Liliom, Yuji Goto, József Kardos
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	amyloidosis protein aggregation β<sub>2</sub>-microglobulin dialysis-related amyloidosis protein stability ion-pairs Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/dea39e0efe244054b9a06e94524de24d
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Pathogenic D76N Variant of β<sub>2</sub>-Microglobulin: Synergy of Diverse Effects in Both the Native and Amyloid States

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