Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative

Abstract We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration r...

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Autores principales:	Pamela Piscitelli, Francesca Viazzi, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Roberto Pontremoli, Salvatore De Cosmo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dea47f590255476cadea339397e8756a
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spelling	oai:doaj.org-article:dea47f590255476cadea339397e8756a2021-12-02T16:06:24ZPredictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative10.1038/s41598-017-03551-w2045-2322https://doaj.org/article/dea47f590255476cadea339397e8756a2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03551-whttps://doaj.org/toc/2045-2322Abstract We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration rate (eGFR), urinary albumin excretion, HbA1c, lipids, blood pressure. Over a 5-year period 4.3% (n = 115) developed reduced eGFR (<60 ml/min/1.73 m2), 18.0% (n = 477) albuminuria, and 21.0% (n = 559) either one of the renal endpoints (CKD). Odds ratios for eGFR below 90 mL/min/1.73 m2 (1.48, P < 0.001), HbA1c (1.13, P = 0.002), triglycerides (1.04, P = 0.021 by 20 mg/dL), low density lipoprotein cholesterol (LDL-c) (0.95, P = 0.002 by 10 mg/dL) were independently related to the onset of CKD. Known duration of diabetes (1.15, P = 0.014 by 10 years), HbA1c (1.16, P = 0.001), triglycerides (1.05, P = 0.005 by 20 mg/dL), LDL-c (0.95, P = 0.003 by 10 mg/dL), antihypertensive treatment (2.28, P = 0.018) were related to the onset of albuminuria while age and presence of baseline eGFR values between 90 and 60 mL/min/1.73 m2, independently affected the developing of reduced eGFR (OR 1.95, P < 0.001 by 10 years and 2.92, P < 0.001). Patients with type 1 diabetes mellitus and unfavorable CV risk profile are at high risk of developing CKD. The two main traits of CKD share several determinants, although with some specificities.Pamela PiscitelliFrancesca ViazziPaola FiorettoCarlo GiordaAntonio CerielloStefano GenoveseGiuseppina RussoPietro GuidaRoberto PontremoliSalvatore De CosmoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pamela Piscitelli Francesca Viazzi Paola Fioretto Carlo Giorda Antonio Ceriello Stefano Genovese Giuseppina Russo Pietro Guida Roberto Pontremoli Salvatore De Cosmo Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative
description	Abstract We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration rate (eGFR), urinary albumin excretion, HbA1c, lipids, blood pressure. Over a 5-year period 4.3% (n = 115) developed reduced eGFR (<60 ml/min/1.73 m2), 18.0% (n = 477) albuminuria, and 21.0% (n = 559) either one of the renal endpoints (CKD). Odds ratios for eGFR below 90 mL/min/1.73 m2 (1.48, P < 0.001), HbA1c (1.13, P = 0.002), triglycerides (1.04, P = 0.021 by 20 mg/dL), low density lipoprotein cholesterol (LDL-c) (0.95, P = 0.002 by 10 mg/dL) were independently related to the onset of CKD. Known duration of diabetes (1.15, P = 0.014 by 10 years), HbA1c (1.16, P = 0.001), triglycerides (1.05, P = 0.005 by 20 mg/dL), LDL-c (0.95, P = 0.003 by 10 mg/dL), antihypertensive treatment (2.28, P = 0.018) were related to the onset of albuminuria while age and presence of baseline eGFR values between 90 and 60 mL/min/1.73 m2, independently affected the developing of reduced eGFR (OR 1.95, P < 0.001 by 10 years and 2.92, P < 0.001). Patients with type 1 diabetes mellitus and unfavorable CV risk profile are at high risk of developing CKD. The two main traits of CKD share several determinants, although with some specificities.
format	article
author	Pamela Piscitelli Francesca Viazzi Paola Fioretto Carlo Giorda Antonio Ceriello Stefano Genovese Giuseppina Russo Pietro Guida Roberto Pontremoli Salvatore De Cosmo
author_facet	Pamela Piscitelli Francesca Viazzi Paola Fioretto Carlo Giorda Antonio Ceriello Stefano Genovese Giuseppina Russo Pietro Guida Roberto Pontremoli Salvatore De Cosmo
author_sort	Pamela Piscitelli
title	Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative
title_short	Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative
title_full	Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative
title_fullStr	Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative
title_full_unstemmed	Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative
title_sort	predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the amd annals initiative
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dea47f590255476cadea339397e8756a
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Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative

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