The frequency of non-pathologically thin corneas in young healthy adults

Hannah Rashdan, Manali Shah, Danielle M RobertsonDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USAPurpose: Measurement of normal corneal thickness and corneal epithelial thickness is important in keratorefractive surgery, glaucoma, following extended contact lens wear, and...

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Autores principales:	Rashdan H, Shah M, Robertson DM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	cornea epithelial stroma thickness OCT Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/dea5335644fa4c3ca2a69d3c1e364e8a
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spelling	oai:doaj.org-article:dea5335644fa4c3ca2a69d3c1e364e8a2021-12-02T07:51:32ZThe frequency of non-pathologically thin corneas in young healthy adults1177-5483https://doaj.org/article/dea5335644fa4c3ca2a69d3c1e364e8a2019-07-01T00:00:00Zhttps://www.dovepress.com/the-frequency-of-non-pathologically-thin-corneas-in-young-healthy-adul-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Hannah Rashdan, Manali Shah, Danielle M RobertsonDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USAPurpose: Measurement of normal corneal thickness and corneal epithelial thickness is important in keratorefractive surgery, glaucoma, following extended contact lens wear, and in patients with corneal disease. Clinically, a central corneal thickness less than 500 μm is considered to be moderately-to-extremely thin. The purpose of this study was to compare biological differences in patients with clinically thin compared to normal corneal thickness values in healthy young adults using Fourier domain optical coherence tomography.Patients and methods: In total, 168 eyes from 84 patients aged 19–38 years were scanned using an Avanti optical coherence tomographer. To eliminate circadian effects on corneal thickness, all patients were scanned within a 4-hour window. Corneal thickness was measured across the central 6 mm of the cornea. Total central corneal thickness, corneal epithelial thickness, and corneal stromal thickness were compared between males and females and tested for correlations with age, use of systemic hormones, degree of myopia, and corneal curvature.Results: The average central corneal thickness for males and females was 540.5±32.0 μm and 525.2±33.0 μm, respectively (P=0.020). Thirty-eight eyes had corneal thickness measurements below 500 μm; 12% (6 eyes) from males and 28% (16 eyes) from females (P=0.008). All women with corneas below 500 μm were bilaterally thin. This finding differed for men. Corneal thinning was not associated with age, use of systemic hormones, or degree of myopia. Females had steeper keratometry (K) readings (P=0.01 for flat K, P=0.002 for steep K) than males. No differences in layer offset values between normal thickness corneas and thin corneas were evident, suggesting that the reduced thickness was not pathological.Conclusion: The results of this study indicate that a subpopulation of healthy young adults have non-pathologically thin corneas, well below 500 μm; and that these thinner corneas are more frequent in females. This underscores the importance of accurate corneal thickness measurements prior to keratorefractive surgery and when evaluating intraocular pressure in glaucoma.Keywords: cornea, epithelial, stroma, thickness, OCTRashdan HShah MRobertson DMDove Medical PressarticlecorneaepithelialstromathicknessOCTOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1123-1135 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	cornea epithelial stroma thickness OCT Ophthalmology RE1-994
spellingShingle	cornea epithelial stroma thickness OCT Ophthalmology RE1-994 Rashdan H Shah M Robertson DM The frequency of non-pathologically thin corneas in young healthy adults
description	Hannah Rashdan, Manali Shah, Danielle M RobertsonDepartment of Ophthalmology, UT Southwestern Medical Center, Dallas, TX, USAPurpose: Measurement of normal corneal thickness and corneal epithelial thickness is important in keratorefractive surgery, glaucoma, following extended contact lens wear, and in patients with corneal disease. Clinically, a central corneal thickness less than 500 μm is considered to be moderately-to-extremely thin. The purpose of this study was to compare biological differences in patients with clinically thin compared to normal corneal thickness values in healthy young adults using Fourier domain optical coherence tomography.Patients and methods: In total, 168 eyes from 84 patients aged 19–38 years were scanned using an Avanti optical coherence tomographer. To eliminate circadian effects on corneal thickness, all patients were scanned within a 4-hour window. Corneal thickness was measured across the central 6 mm of the cornea. Total central corneal thickness, corneal epithelial thickness, and corneal stromal thickness were compared between males and females and tested for correlations with age, use of systemic hormones, degree of myopia, and corneal curvature.Results: The average central corneal thickness for males and females was 540.5±32.0 μm and 525.2±33.0 μm, respectively (P=0.020). Thirty-eight eyes had corneal thickness measurements below 500 μm; 12% (6 eyes) from males and 28% (16 eyes) from females (P=0.008). All women with corneas below 500 μm were bilaterally thin. This finding differed for men. Corneal thinning was not associated with age, use of systemic hormones, or degree of myopia. Females had steeper keratometry (K) readings (P=0.01 for flat K, P=0.002 for steep K) than males. No differences in layer offset values between normal thickness corneas and thin corneas were evident, suggesting that the reduced thickness was not pathological.Conclusion: The results of this study indicate that a subpopulation of healthy young adults have non-pathologically thin corneas, well below 500 μm; and that these thinner corneas are more frequent in females. This underscores the importance of accurate corneal thickness measurements prior to keratorefractive surgery and when evaluating intraocular pressure in glaucoma.Keywords: cornea, epithelial, stroma, thickness, OCT
format	article
author	Rashdan H Shah M Robertson DM
author_facet	Rashdan H Shah M Robertson DM
author_sort	Rashdan H
title	The frequency of non-pathologically thin corneas in young healthy adults
title_short	The frequency of non-pathologically thin corneas in young healthy adults
title_full	The frequency of non-pathologically thin corneas in young healthy adults
title_fullStr	The frequency of non-pathologically thin corneas in young healthy adults
title_full_unstemmed	The frequency of non-pathologically thin corneas in young healthy adults
title_sort	frequency of non-pathologically thin corneas in young healthy adults
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/dea5335644fa4c3ca2a69d3c1e364e8a
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The frequency of non-pathologically thin corneas in young healthy adults

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