Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.

Genetic aberrations of DNA repair enzymes are known to be common events and to be associated with different cancer entities. Aim of the following study was to analyze the genetic association of rs1136410 (Val762Ala) in PARP1 gene with the risk of breast cancer using genotypic assays and insilico str...

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Autores principales:	Mohammad Alanazi, Akbar Ali Khan Pathan, Zainularifeen Abduljaleel, Jilani P Shaik, Huda A Alabdulkarim, Abdelhabib Semlali, Mohammad D Bazzi, Narasimha Reddy Parine
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dea591a941e548e9b2aeb25e864ed077
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spelling	oai:doaj.org-article:dea591a941e548e9b2aeb25e864ed0772021-11-18T08:39:13ZAssociation between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.1932-620310.1371/journal.pone.0085541https://doaj.org/article/dea591a941e548e9b2aeb25e864ed0772013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24392019/?tool=EBIhttps://doaj.org/toc/1932-6203Genetic aberrations of DNA repair enzymes are known to be common events and to be associated with different cancer entities. Aim of the following study was to analyze the genetic association of rs1136410 (Val762Ala) in PARP1 gene with the risk of breast cancer using genotypic assays and insilico structural predictions. Genotypic analysis of individual locus showed statistically significant association of Val762Ala with increased susceptibility to breast cancer. Protein structural analysis was performed with Val762Ala variant allele and compared with the predicted native protein structure. Protein prediction analysis showed that this nsSNP may cause changes in the protein structure and it is associated with the disease. In addition to the native and mutant 3D structures of PARP1 were also analyzed using solvent accessibility models for further protein stability confirmation. Taken together, this the first study that confirmed Val762Ala variant has functional effect and structural impact on the PARP1 and may play an important role in breast cancer progression in Saudi population.Mohammad AlanaziAkbar Ali Khan PathanZainularifeen AbduljaleelJilani P ShaikHuda A AlabdulkarimAbdelhabib SemlaliMohammad D BazziNarasimha Reddy ParinePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e85541 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad Alanazi Akbar Ali Khan Pathan Zainularifeen Abduljaleel Jilani P Shaik Huda A Alabdulkarim Abdelhabib Semlali Mohammad D Bazzi Narasimha Reddy Parine Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.
description	Genetic aberrations of DNA repair enzymes are known to be common events and to be associated with different cancer entities. Aim of the following study was to analyze the genetic association of rs1136410 (Val762Ala) in PARP1 gene with the risk of breast cancer using genotypic assays and insilico structural predictions. Genotypic analysis of individual locus showed statistically significant association of Val762Ala with increased susceptibility to breast cancer. Protein structural analysis was performed with Val762Ala variant allele and compared with the predicted native protein structure. Protein prediction analysis showed that this nsSNP may cause changes in the protein structure and it is associated with the disease. In addition to the native and mutant 3D structures of PARP1 were also analyzed using solvent accessibility models for further protein stability confirmation. Taken together, this the first study that confirmed Val762Ala variant has functional effect and structural impact on the PARP1 and may play an important role in breast cancer progression in Saudi population.
format	article
author	Mohammad Alanazi Akbar Ali Khan Pathan Zainularifeen Abduljaleel Jilani P Shaik Huda A Alabdulkarim Abdelhabib Semlali Mohammad D Bazzi Narasimha Reddy Parine
author_facet	Mohammad Alanazi Akbar Ali Khan Pathan Zainularifeen Abduljaleel Jilani P Shaik Huda A Alabdulkarim Abdelhabib Semlali Mohammad D Bazzi Narasimha Reddy Parine
author_sort	Mohammad Alanazi
title	Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.
title_short	Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.
title_full	Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.
title_fullStr	Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.
title_full_unstemmed	Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.
title_sort	association between parp-1 v762a polymorphism and breast cancer susceptibility in saudi population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/dea591a941e548e9b2aeb25e864ed077
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Association between PARP-1 V762A polymorphism and breast cancer susceptibility in Saudi population.

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