Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation

Abstract Myogenic differentiation results in different cell type cooperation, but the molecules involved in the myogenic cell activation remain elusive. Here, we show that muscle-resident pre-adipocytes promote myogenic differentiation through the secretion of factors. Using proteomic and transcript...

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Autores principales:	Thierry Rouaud, Nader Siami, Tanaelle Dupas, Pascal Gervier, Marie-France Gardahaut, Gwenola Auda-Boucher, Christophe Thiriet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dea7c4b9b26a4bb68c671c4412cc8590
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spelling	oai:doaj.org-article:dea7c4b9b26a4bb68c671c4412cc85902021-12-02T15:06:12ZComplement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation10.1038/s41598-017-00099-72045-2322https://doaj.org/article/dea7c4b9b26a4bb68c671c4412cc85902017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00099-7https://doaj.org/toc/2045-2322Abstract Myogenic differentiation results in different cell type cooperation, but the molecules involved in the myogenic cell activation remain elusive. Here, we show that muscle-resident pre-adipocytes promote myogenic differentiation through the secretion of factors. Using proteomic and transcriptomic analyses, we identified that proliferative adipogenic lineage cells produce and secrete a key factor of the innate immune system, the complement C3. Cell culture experiments revealed that C3 promotes the differentiation of myogenic progenitors following internalisation of the immune molecule. These data demonstrate that the third component of the complement system, which is a pivotal factor in the immune response to pathogens, is also involved in the differentiation of myogenic progenitor cells.Thierry RouaudNader SiamiTanaelle DupasPascal GervierMarie-France GardahautGwenola Auda-BoucherChristophe ThirietNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thierry Rouaud Nader Siami Tanaelle Dupas Pascal Gervier Marie-France Gardahaut Gwenola Auda-Boucher Christophe Thiriet Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation
description	Abstract Myogenic differentiation results in different cell type cooperation, but the molecules involved in the myogenic cell activation remain elusive. Here, we show that muscle-resident pre-adipocytes promote myogenic differentiation through the secretion of factors. Using proteomic and transcriptomic analyses, we identified that proliferative adipogenic lineage cells produce and secrete a key factor of the innate immune system, the complement C3. Cell culture experiments revealed that C3 promotes the differentiation of myogenic progenitors following internalisation of the immune molecule. These data demonstrate that the third component of the complement system, which is a pivotal factor in the immune response to pathogens, is also involved in the differentiation of myogenic progenitor cells.
format	article
author	Thierry Rouaud Nader Siami Tanaelle Dupas Pascal Gervier Marie-France Gardahaut Gwenola Auda-Boucher Christophe Thiriet
author_facet	Thierry Rouaud Nader Siami Tanaelle Dupas Pascal Gervier Marie-France Gardahaut Gwenola Auda-Boucher Christophe Thiriet
author_sort	Thierry Rouaud
title	Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation
title_short	Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation
title_full	Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation
title_fullStr	Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation
title_full_unstemmed	Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation
title_sort	complement c3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/dea7c4b9b26a4bb68c671c4412cc8590
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Complement C3 of the innate immune system secreted by muscle adipogenic cells promotes myogenic differentiation

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