Spatial structure of TLR4 transmembrane domain in bicelles provides the insight into the receptor activation mechanism

Abstract Toll-like receptors (TLRs) play a key role in the innate and adaptive immune systems. While a lot of structural data is available for the extracellular and cytoplasmic domains of TLRs, and a model of the dimeric full-length TLR3 receptor in the active state was build, the conformation of th...

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Autores principales: Konstantin S. Mineev, Sergey A. Goncharuk, Marina V. Goncharuk, Pavel E. Volynsky, Ekaterina V. Novikova, Alexander S. Aresinev
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/dea916c8e3f84fe9aa8fca25b00f37a1
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