Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch

Short-lived RNA folding intermediates have important roles in the folding of RNA. Here, the authors combine 15N relaxation dispersion NMR with chemical probing to visualise one of these intermediates, and are able to show it is a secondary structural switch, that might help with folding.

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Bibliographic Details
Main Authors:	Yi Xue, Brant Gracia, Daniel Herschlag, Rick Russell, Hashim M. Al-Hashimi
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/deaa5227c7d8451dba01c449d0c89643
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id	oai:doaj.org-article:deaa5227c7d8451dba01c449d0c89643
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spelling	oai:doaj.org-article:deaa5227c7d8451dba01c449d0c896432021-12-02T15:33:49ZVisualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch10.1038/ncomms117682041-1723https://doaj.org/article/deaa5227c7d8451dba01c449d0c896432016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11768https://doaj.org/toc/2041-1723Short-lived RNA folding intermediates have important roles in the folding of RNA. Here, the authors combine 15N relaxation dispersion NMR with chemical probing to visualise one of these intermediates, and are able to show it is a secondary structural switch, that might help with folding.Yi XueBrant GraciaDaniel HerschlagRick RussellHashim M. Al-HashimiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Xue Brant Gracia Daniel Herschlag Rick Russell Hashim M. Al-Hashimi Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch
description	Short-lived RNA folding intermediates have important roles in the folding of RNA. Here, the authors combine 15N relaxation dispersion NMR with chemical probing to visualise one of these intermediates, and are able to show it is a secondary structural switch, that might help with folding.
format	article
author	Yi Xue Brant Gracia Daniel Herschlag Rick Russell Hashim M. Al-Hashimi
author_facet	Yi Xue Brant Gracia Daniel Herschlag Rick Russell Hashim M. Al-Hashimi
author_sort	Yi Xue
title	Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch
title_short	Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch
title_full	Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch
title_fullStr	Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch
title_full_unstemmed	Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch
title_sort	visualizing the formation of an rna folding intermediate through a fast highly modular secondary structure switch
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/deaa5227c7d8451dba01c449d0c89643
work_keys_str_mv	AT yixue visualizingtheformationofanrnafoldingintermediatethroughafasthighlymodularsecondarystructureswitch AT brantgracia visualizingtheformationofanrnafoldingintermediatethroughafasthighlymodularsecondarystructureswitch AT danielherschlag visualizingtheformationofanrnafoldingintermediatethroughafasthighlymodularsecondarystructureswitch AT rickrussell visualizingtheformationofanrnafoldingintermediatethroughafasthighlymodularsecondarystructureswitch AT hashimmalhashimi visualizingtheformationofanrnafoldingintermediatethroughafasthighlymodularsecondarystructureswitch
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Visualizing the formation of an RNA folding intermediate through a fast highly modular secondary structure switch

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