Economic burden of human papillomavirus-related diseases in Italy.

<h4>Introduction</h4>Human papilloma virus (HPV) genotypes 6, 11, 16, and 18 impose a substantial burden of direct costs on the Italian National Health Service that has never been quantified fully. The main objective of the present study was to address this gap: (1) by estimating the tot...

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Autores principales:	Gianluca Baio, Alessandro Capone, Andrea Marcellusi, Francesco Saverio Mennini, Giampiero Favato
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/deadf48a240c44f19bc71f76e90185e1
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spelling	oai:doaj.org-article:deadf48a240c44f19bc71f76e90185e12021-11-18T08:07:55ZEconomic burden of human papillomavirus-related diseases in Italy.1932-620310.1371/journal.pone.0049699https://doaj.org/article/deadf48a240c44f19bc71f76e90185e12012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23185412/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Human papilloma virus (HPV) genotypes 6, 11, 16, and 18 impose a substantial burden of direct costs on the Italian National Health Service that has never been quantified fully. The main objective of the present study was to address this gap: (1) by estimating the total direct medical costs associated with nine major HPV-related diseases, namely invasive cervical cancer, cervical dysplasia, cancer of the vulva, vagina, anus, penis, and head and neck, anogenital warts, and recurrent respiratory papillomatosis, and (2) by providing an aggregate measure of the total economic burden attributable to HPV 6, 11, 16, and 18 infection.<h4>Methods</h4>For each of the nine conditions, we used available Italian secondary data to estimate the lifetime cost per case, the number of incident cases of each disease, the total economic burden, and the relative prevalence of HPV types 6, 11, 16, and 18, in order to estimate the aggregate fraction of the total economic burden attributable to HPV infection.<h4>Results</h4>The total direct costs (expressed in 2011 Euro) associated with the annual incident cases of the nine HPV-related conditions included in the analysis were estimated to be €528.6 million, with a plausible range of €480.1-686.2 million. The fraction attributable to HPV 6, 11, 16, and 18 was €291.0 (range €274.5-315.7 million), accounting for approximately 55% of the total annual burden of HPV-related disease in Italy.<h4>Conclusions</h4>The results provided a plausible estimate of the significant economic burden imposed by the most prevalent HPV-related diseases on the Italian welfare system. The fraction of the total direct lifetime costs attributable to HPV 6, 11, 16, and 18 infections, and the economic burden of noncervical HPV-related diseases carried by men, were found to be cost drivers relevant to the making of informed decisions about future investments in programmes of HPV prevention.Gianluca BaioAlessandro CaponeAndrea MarcellusiFrancesco Saverio MenniniGiampiero FavatoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49699 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gianluca Baio Alessandro Capone Andrea Marcellusi Francesco Saverio Mennini Giampiero Favato Economic burden of human papillomavirus-related diseases in Italy.
description	<h4>Introduction</h4>Human papilloma virus (HPV) genotypes 6, 11, 16, and 18 impose a substantial burden of direct costs on the Italian National Health Service that has never been quantified fully. The main objective of the present study was to address this gap: (1) by estimating the total direct medical costs associated with nine major HPV-related diseases, namely invasive cervical cancer, cervical dysplasia, cancer of the vulva, vagina, anus, penis, and head and neck, anogenital warts, and recurrent respiratory papillomatosis, and (2) by providing an aggregate measure of the total economic burden attributable to HPV 6, 11, 16, and 18 infection.<h4>Methods</h4>For each of the nine conditions, we used available Italian secondary data to estimate the lifetime cost per case, the number of incident cases of each disease, the total economic burden, and the relative prevalence of HPV types 6, 11, 16, and 18, in order to estimate the aggregate fraction of the total economic burden attributable to HPV infection.<h4>Results</h4>The total direct costs (expressed in 2011 Euro) associated with the annual incident cases of the nine HPV-related conditions included in the analysis were estimated to be €528.6 million, with a plausible range of €480.1-686.2 million. The fraction attributable to HPV 6, 11, 16, and 18 was €291.0 (range €274.5-315.7 million), accounting for approximately 55% of the total annual burden of HPV-related disease in Italy.<h4>Conclusions</h4>The results provided a plausible estimate of the significant economic burden imposed by the most prevalent HPV-related diseases on the Italian welfare system. The fraction of the total direct lifetime costs attributable to HPV 6, 11, 16, and 18 infections, and the economic burden of noncervical HPV-related diseases carried by men, were found to be cost drivers relevant to the making of informed decisions about future investments in programmes of HPV prevention.
format	article
author	Gianluca Baio Alessandro Capone Andrea Marcellusi Francesco Saverio Mennini Giampiero Favato
author_facet	Gianluca Baio Alessandro Capone Andrea Marcellusi Francesco Saverio Mennini Giampiero Favato
author_sort	Gianluca Baio
title	Economic burden of human papillomavirus-related diseases in Italy.
title_short	Economic burden of human papillomavirus-related diseases in Italy.
title_full	Economic burden of human papillomavirus-related diseases in Italy.
title_fullStr	Economic burden of human papillomavirus-related diseases in Italy.
title_full_unstemmed	Economic burden of human papillomavirus-related diseases in Italy.
title_sort	economic burden of human papillomavirus-related diseases in italy.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/deadf48a240c44f19bc71f76e90185e1
work_keys_str_mv	AT gianlucabaio economicburdenofhumanpapillomavirusrelateddiseasesinitaly AT alessandrocapone economicburdenofhumanpapillomavirusrelateddiseasesinitaly AT andreamarcellusi economicburdenofhumanpapillomavirusrelateddiseasesinitaly AT francescosaveriomennini economicburdenofhumanpapillomavirusrelateddiseasesinitaly AT giampierofavato economicburdenofhumanpapillomavirusrelateddiseasesinitaly
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Economic burden of human papillomavirus-related diseases in Italy.

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