The peopling of Europe from the mitochondrial haplogroup U5 perspective.

It is generally accepted that the most ancient European mitochondrial haplogroup, U5, has evolved essentially in Europe. To resolve the phylogeny of this haplogroup, we completely sequenced 113 mitochondrial genomes (79 U5a and 34 U5b) of central and eastern Europeans (Czechs, Slovaks, Poles, Russia...

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Autores principales:	Boris Malyarchuk, Miroslava Derenko, Tomasz Grzybowski, Maria Perkova, Urszula Rogalla, Tomas Vanecek, Iosif Tsybovsky
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/deb015206d1942c1ac1dcd336d4b97f1
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id	oai:doaj.org-article:deb015206d1942c1ac1dcd336d4b97f1
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spelling	oai:doaj.org-article:deb015206d1942c1ac1dcd336d4b97f12021-11-25T06:24:24ZThe peopling of Europe from the mitochondrial haplogroup U5 perspective.1932-620310.1371/journal.pone.0010285https://doaj.org/article/deb015206d1942c1ac1dcd336d4b97f12010-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20422015/?tool=EBIhttps://doaj.org/toc/1932-6203It is generally accepted that the most ancient European mitochondrial haplogroup, U5, has evolved essentially in Europe. To resolve the phylogeny of this haplogroup, we completely sequenced 113 mitochondrial genomes (79 U5a and 34 U5b) of central and eastern Europeans (Czechs, Slovaks, Poles, Russians and Belorussians), and reconstructed a detailed phylogenetic tree, that incorporates previously published data. Molecular dating suggests that the coalescence time estimate for the U5 is approximately 25-30 thousand years (ky), and approximately 16-20 and approximately 20-24 ky for its subhaplogroups U5a and U5b, respectively. Phylogeographic analysis reveals that expansions of U5 subclusters started earlier in central and southern Europe, than in eastern Europe. In addition, during the Last Glacial Maximum central Europe (probably, the Carpathian Basin) apparently represented the area of intermingling between human flows from refugial zones in the Balkans, the Mediterranean coastline and the Pyrenees. Age estimations amounting for many U5 subclusters in eastern Europeans to approximately 15 ky ago and less are consistent with the view that during the Ice Age eastern Europe was an inhospitable place for modern humans.Boris MalyarchukMiroslava DerenkoTomasz GrzybowskiMaria PerkovaUrszula RogallaTomas VanecekIosif TsybovskyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 4, p e10285 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Boris Malyarchuk Miroslava Derenko Tomasz Grzybowski Maria Perkova Urszula Rogalla Tomas Vanecek Iosif Tsybovsky The peopling of Europe from the mitochondrial haplogroup U5 perspective.
description	It is generally accepted that the most ancient European mitochondrial haplogroup, U5, has evolved essentially in Europe. To resolve the phylogeny of this haplogroup, we completely sequenced 113 mitochondrial genomes (79 U5a and 34 U5b) of central and eastern Europeans (Czechs, Slovaks, Poles, Russians and Belorussians), and reconstructed a detailed phylogenetic tree, that incorporates previously published data. Molecular dating suggests that the coalescence time estimate for the U5 is approximately 25-30 thousand years (ky), and approximately 16-20 and approximately 20-24 ky for its subhaplogroups U5a and U5b, respectively. Phylogeographic analysis reveals that expansions of U5 subclusters started earlier in central and southern Europe, than in eastern Europe. In addition, during the Last Glacial Maximum central Europe (probably, the Carpathian Basin) apparently represented the area of intermingling between human flows from refugial zones in the Balkans, the Mediterranean coastline and the Pyrenees. Age estimations amounting for many U5 subclusters in eastern Europeans to approximately 15 ky ago and less are consistent with the view that during the Ice Age eastern Europe was an inhospitable place for modern humans.
format	article
author	Boris Malyarchuk Miroslava Derenko Tomasz Grzybowski Maria Perkova Urszula Rogalla Tomas Vanecek Iosif Tsybovsky
author_facet	Boris Malyarchuk Miroslava Derenko Tomasz Grzybowski Maria Perkova Urszula Rogalla Tomas Vanecek Iosif Tsybovsky
author_sort	Boris Malyarchuk
title	The peopling of Europe from the mitochondrial haplogroup U5 perspective.
title_short	The peopling of Europe from the mitochondrial haplogroup U5 perspective.
title_full	The peopling of Europe from the mitochondrial haplogroup U5 perspective.
title_fullStr	The peopling of Europe from the mitochondrial haplogroup U5 perspective.
title_full_unstemmed	The peopling of Europe from the mitochondrial haplogroup U5 perspective.
title_sort	peopling of europe from the mitochondrial haplogroup u5 perspective.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/deb015206d1942c1ac1dcd336d4b97f1
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The peopling of Europe from the mitochondrial haplogroup U5 perspective.

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