Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex

Bacterial wall biosynthesis is a complex process that requires the coordination of multiple enzymes. Here, the authors structurally characterize the PBP2:MreC complex involved in peptidoglycan elongation and cross-linking, and demonstrate that its disruption leads to loss of H. pylori shape and inab...

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Autores principales:	Carlos Contreras-Martel, Alexandre Martins, Chantal Ecobichon, Daniel Maragno Trindade, Pierre-Jean Matteï, Samia Hicham, Pierre Hardouin, Meriem El Ghachi, Ivo G. Boneca, Andréa Dessen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/deb2c2d026dc4bb99411c94e9bd2ad5a
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spelling	oai:doaj.org-article:deb2c2d026dc4bb99411c94e9bd2ad5a2021-12-02T15:38:54ZMolecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex10.1038/s41467-017-00783-22041-1723https://doaj.org/article/deb2c2d026dc4bb99411c94e9bd2ad5a2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00783-2https://doaj.org/toc/2041-1723Bacterial wall biosynthesis is a complex process that requires the coordination of multiple enzymes. Here, the authors structurally characterize the PBP2:MreC complex involved in peptidoglycan elongation and cross-linking, and demonstrate that its disruption leads to loss of H. pylori shape and inability to sustain growth.Carlos Contreras-MartelAlexandre MartinsChantal EcobichonDaniel Maragno TrindadePierre-Jean MatteïSamia HichamPierre HardouinMeriem El GhachiIvo G. BonecaAndréa DessenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carlos Contreras-Martel Alexandre Martins Chantal Ecobichon Daniel Maragno Trindade Pierre-Jean Matteï Samia Hicham Pierre Hardouin Meriem El Ghachi Ivo G. Boneca Andréa Dessen Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex
description	Bacterial wall biosynthesis is a complex process that requires the coordination of multiple enzymes. Here, the authors structurally characterize the PBP2:MreC complex involved in peptidoglycan elongation and cross-linking, and demonstrate that its disruption leads to loss of H. pylori shape and inability to sustain growth.
format	article
author	Carlos Contreras-Martel Alexandre Martins Chantal Ecobichon Daniel Maragno Trindade Pierre-Jean Matteï Samia Hicham Pierre Hardouin Meriem El Ghachi Ivo G. Boneca Andréa Dessen
author_facet	Carlos Contreras-Martel Alexandre Martins Chantal Ecobichon Daniel Maragno Trindade Pierre-Jean Matteï Samia Hicham Pierre Hardouin Meriem El Ghachi Ivo G. Boneca Andréa Dessen
author_sort	Carlos Contreras-Martel
title	Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex
title_short	Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex
title_full	Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex
title_fullStr	Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex
title_full_unstemmed	Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex
title_sort	molecular architecture of the pbp2–mrec core bacterial cell wall synthesis complex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/deb2c2d026dc4bb99411c94e9bd2ad5a
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_version_	1718386078847598592

Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex

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