Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

Abstract Aminoquinoline derivatives were evaluated against a panel of receptors/channels/transporters in radioligand binding experiments. One of these derivatives (DCUK-OEt) displayed micromolar affinity for brain γ-aminobutyric acid type A (GABAA) receptors. DCUK-OEt was shown to be a positive allo...

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Autores principales: Cecilia M. Borghese, Melissa Herman, Lawrence D. Snell, Keri J. Lawrence, Hyun-Young Lee, Donald S. Backos, Lauren A. Vanderlinden, R. Adron Harris, Marisa Roberto, Paula L. Hoffman, Boris Tabakoff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/deb9d0e8116a4679aa8f5c369a838e42
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