Identification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study

Peng Ju Liu,1 Hui Ping Lou,2 Yan Ning Zhu3 1Department of Clinical Nutrition, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People’s Republic of China; 2Medical Examination Center, Peking Union Medical College Hospital, Chi...

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Autores principales:	Liu PJ, Lou HP, Zhu YN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	nonalcoholic fatty liver disease hepatic steatosis anthropometric index hypertriglyceridemic waist phenotype menopause Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/deba5ce7275046eca5fb50723ba65ee8
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spelling	oai:doaj.org-article:deba5ce7275046eca5fb50723ba65ee82021-12-02T17:06:25ZIdentification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study1178-7007https://doaj.org/article/deba5ce7275046eca5fb50723ba65ee82021-03-01T00:00:00Zhttps://www.dovepress.com/identification-of-hepatic-steatosis-in-premenopausal-and-postmenopausa-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Peng Ju Liu,1 Hui Ping Lou,2 Yan Ning Zhu3 1Department of Clinical Nutrition, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People’s Republic of China; 2Medical Examination Center, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Peng Ju LiuDepartment of Clinical Nutrition, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, #1 Shuaifuyuan, Dongcheng District, Beijing, 100730, People’s Republic of ChinaTel +86 10-69155550Fax +86 10-69155551Email lpjjia@126.comBackground: The hypertriglyceridemic waist phenotype (HWP) has exhibited a strong association with metabolic syndrome, a condition closely linked with nonalcoholic fatty liver disease (NAFLD). However, no study has investigated whether the HWP can accurately predict NAFLD among premenopausal and postmenopausal women or whether alternative anthropometric indexes could replace waist circumference (WC) in the HWP. We examined the power of phenotypes combining triglyceride (TG) levels with anthropometric indexes such as body mass index (BMI), WC, waist-to-hip ratio, waist-to-height ratio, and percent body fat, to detect NAFLD among premenopausal and postmenopausal women.Methods: We conducted a cross-sectional study of 1125 premenopausal women and 654 postmenopausal women who had received an annual health checkup. For all the participating women, we measured both anthropometric and biochemical indexes, such as serum lipid levels. NAFLD diagnoses were made on the basis of abdominal ultrasonography findings. The receiver operating characteristic curve and area under the curve (AUC) were used to evaluate the indicators’ ability to detect NAFLD.Results: Among the indicators of hepatic steatosis, the combined phenotypes of TG level (≥ 1.50 mmol/L) and BMI (≥ 24.0 kg/m2) exhibited the largest AUC (0.841, 95%confidence interval [CI] 0.812– 0.871, P< 0.001) for premenopausal women, whereas WC alone exhibited the highest predictive potential (0.765, 95% CI 0.729– 0.801, P< 0.001) for postmenopausal women.Conclusion: Out of all the phenotypes combining a single anthropometric index with TG level or WC and TG level, the combination of TG level and BMI was the best indicator of NAFLD for premenopausal women. For screening NAFLD in postmenopausal women, WC alone was superior to all other indicators.Keywords: nonalcoholic fatty liver disease, hepatic steatosis, anthropometric index, hypertriglyceridemic waist phenotype, menopauseLiu PJLou HPZhu YNDove Medical Pressarticlenonalcoholic fatty liver diseasehepatic steatosisanthropometric indexhypertriglyceridemic waist phenotypemenopauseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1339-1347 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nonalcoholic fatty liver disease hepatic steatosis anthropometric index hypertriglyceridemic waist phenotype menopause Specialties of internal medicine RC581-951
spellingShingle	nonalcoholic fatty liver disease hepatic steatosis anthropometric index hypertriglyceridemic waist phenotype menopause Specialties of internal medicine RC581-951 Liu PJ Lou HP Zhu YN Identification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study
description	Peng Ju Liu,1 Hui Ping Lou,2 Yan Ning Zhu3 1Department of Clinical Nutrition, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People’s Republic of China; 2Medical Examination Center, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People’s Republic of China; 3Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Peng Ju LiuDepartment of Clinical Nutrition, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, #1 Shuaifuyuan, Dongcheng District, Beijing, 100730, People’s Republic of ChinaTel +86 10-69155550Fax +86 10-69155551Email lpjjia@126.comBackground: The hypertriglyceridemic waist phenotype (HWP) has exhibited a strong association with metabolic syndrome, a condition closely linked with nonalcoholic fatty liver disease (NAFLD). However, no study has investigated whether the HWP can accurately predict NAFLD among premenopausal and postmenopausal women or whether alternative anthropometric indexes could replace waist circumference (WC) in the HWP. We examined the power of phenotypes combining triglyceride (TG) levels with anthropometric indexes such as body mass index (BMI), WC, waist-to-hip ratio, waist-to-height ratio, and percent body fat, to detect NAFLD among premenopausal and postmenopausal women.Methods: We conducted a cross-sectional study of 1125 premenopausal women and 654 postmenopausal women who had received an annual health checkup. For all the participating women, we measured both anthropometric and biochemical indexes, such as serum lipid levels. NAFLD diagnoses were made on the basis of abdominal ultrasonography findings. The receiver operating characteristic curve and area under the curve (AUC) were used to evaluate the indicators’ ability to detect NAFLD.Results: Among the indicators of hepatic steatosis, the combined phenotypes of TG level (≥ 1.50 mmol/L) and BMI (≥ 24.0 kg/m2) exhibited the largest AUC (0.841, 95%confidence interval [CI] 0.812– 0.871, P< 0.001) for premenopausal women, whereas WC alone exhibited the highest predictive potential (0.765, 95% CI 0.729– 0.801, P< 0.001) for postmenopausal women.Conclusion: Out of all the phenotypes combining a single anthropometric index with TG level or WC and TG level, the combination of TG level and BMI was the best indicator of NAFLD for premenopausal women. For screening NAFLD in postmenopausal women, WC alone was superior to all other indicators.Keywords: nonalcoholic fatty liver disease, hepatic steatosis, anthropometric index, hypertriglyceridemic waist phenotype, menopause
format	article
author	Liu PJ Lou HP Zhu YN
author_facet	Liu PJ Lou HP Zhu YN
author_sort	Liu PJ
title	Identification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study
title_short	Identification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study
title_full	Identification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study
title_fullStr	Identification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study
title_full_unstemmed	Identification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study
title_sort	identification of hepatic steatosis in premenopausal and postmenopausal women based on phenotypes combining triglyceride levels and anthropometric indices: a cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/deba5ce7275046eca5fb50723ba65ee8
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_version_	1718381644488900608

Identification of Hepatic Steatosis in Premenopausal and Postmenopausal Women Based on Phenotypes Combining Triglyceride Levels and Anthropometric Indices: A Cross-Sectional Study

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