Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium
Ryou Watanabe, Toru Nakazawa, Shunji Yokokura, Akira Kubota, Hisayo Kubota, Kohji NishidaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, JapanBackground: In vitro studies have suggested the corneal cytotoxicity of third-generation fluoroquinolone levoflox...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2010
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| Acceso en línea: | https://doaj.org/article/debfb31372114e5fa7da333a66703145 |
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| Sumario: | Ryou Watanabe, Toru Nakazawa, Shunji Yokokura, Akira Kubota, Hisayo Kubota, Kohji NishidaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, JapanBackground: In vitro studies have suggested the corneal cytotoxicity of third-generation fluoroquinolone levofloxacin (LVFX) and fourth-generation fluoroquinolone moxifloxacin hydrochloride (MFLX) among fluoroquinolone antibacterial eye drops. This study investigated the effects of these two eye drops on the human cornea in vivo.Methods: We evaluated 30 healthy adults (19 men and 11 women, 38.3 ± 6.3 years old). Each subject received an LVFX ophthalmic solution 0.5% in one eye and an MFLX ophthalmic solution 0.5% in the other eye three times daily for 7 days. Functional and morphological corneal changes before and after instillation were evaluated through ophthalmic examinations including breakup time of tear film (BUT) as measured by fluorescein staining and DR-1, Schirmer I test, Heidelberg Retina Tomograph II Rostock Cornea Module (HRTII-RCM), specular microscope, and Pentacum examination.Results: Both the LVFX and MFLX groups had no significant change in each examination before and after instillation. There was also no statistically significant difference in measurements after the 7-day instillation between the groups.Conclusion: Our study results suggest that as with LVFX, MFLX used in a normal clinical setting is unlikely to cause any obvious adverse effects on human normal cornea.Keywords: cornea, fluoroquinolones, ocular surface, toxicity |
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