Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium

Ryou Watanabe, Toru Nakazawa, Shunji Yokokura, Akira Kubota, Hisayo Kubota, Kohji NishidaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, JapanBackground: In vitro studies have suggested the corneal cytotoxicity of third-generation fluoroquinolone levoflox...

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Autores principales:	Ryou Watanabe, Toru Nakazawa, Shunji Yokokura, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/debfb31372114e5fa7da333a66703145
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spelling	oai:doaj.org-article:debfb31372114e5fa7da333a667031452021-12-02T04:55:41ZFluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium1177-54671177-5483https://doaj.org/article/debfb31372114e5fa7da333a667031452010-10-01T00:00:00Zhttp://www.dovepress.com/fluoroquinolone-antibacterial-eye-drops-effects-on-normal-human-cornea-a5451https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Ryou Watanabe, Toru Nakazawa, Shunji Yokokura, Akira Kubota, Hisayo Kubota, Kohji NishidaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, JapanBackground: In vitro studies have suggested the corneal cytotoxicity of third-generation fluoroquinolone levofloxacin (LVFX) and fourth-generation fluoroquinolone moxifloxacin hydrochloride (MFLX) among fluoroquinolone antibacterial eye drops. This study investigated the effects of these two eye drops on the human cornea in vivo.Methods: We evaluated 30 healthy adults (19 men and 11 women, 38.3 &plusmn; 6.3 years old). Each subject received an LVFX ophthalmic solution 0.5% in one eye and an MFLX ophthalmic solution 0.5% in the other eye three times daily for 7 days. Functional and morphological corneal changes before and after instillation were evaluated through ophthalmic examinations including breakup time of tear film (BUT) as measured by fluorescein staining and DR-1, Schirmer I test, Heidelberg Retina Tomograph II Rostock Cornea Module (HRTII-RCM), specular microscope, and Pentacum examination.Results: Both the LVFX and MFLX groups had no significant change in each examination before and after instillation. There was also no statistically significant difference in measurements after the 7-day instillation between the groups.Conclusion: Our study results suggest that as with LVFX, MFLX used in a normal clinical setting is unlikely to cause any obvious adverse effects on human normal cornea.Keywords: cornea, fluoroquinolones, ocular surface, toxicity Ryou WatanabeToru NakazawaShunji Yokokuraet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 1181-1187 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Ryou Watanabe Toru Nakazawa Shunji Yokokura et al Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium
description	Ryou Watanabe, Toru Nakazawa, Shunji Yokokura, Akira Kubota, Hisayo Kubota, Kohji NishidaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, JapanBackground: In vitro studies have suggested the corneal cytotoxicity of third-generation fluoroquinolone levofloxacin (LVFX) and fourth-generation fluoroquinolone moxifloxacin hydrochloride (MFLX) among fluoroquinolone antibacterial eye drops. This study investigated the effects of these two eye drops on the human cornea in vivo.Methods: We evaluated 30 healthy adults (19 men and 11 women, 38.3 &plusmn; 6.3 years old). Each subject received an LVFX ophthalmic solution 0.5% in one eye and an MFLX ophthalmic solution 0.5% in the other eye three times daily for 7 days. Functional and morphological corneal changes before and after instillation were evaluated through ophthalmic examinations including breakup time of tear film (BUT) as measured by fluorescein staining and DR-1, Schirmer I test, Heidelberg Retina Tomograph II Rostock Cornea Module (HRTII-RCM), specular microscope, and Pentacum examination.Results: Both the LVFX and MFLX groups had no significant change in each examination before and after instillation. There was also no statistically significant difference in measurements after the 7-day instillation between the groups.Conclusion: Our study results suggest that as with LVFX, MFLX used in a normal clinical setting is unlikely to cause any obvious adverse effects on human normal cornea.Keywords: cornea, fluoroquinolones, ocular surface, toxicity
format	article
author	Ryou Watanabe Toru Nakazawa Shunji Yokokura et al
author_facet	Ryou Watanabe Toru Nakazawa Shunji Yokokura et al
author_sort	Ryou Watanabe
title	Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium
title_short	Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium
title_full	Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium
title_fullStr	Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium
title_full_unstemmed	Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium
title_sort	fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/debfb31372114e5fa7da333a66703145
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_version_	1718400982868557824

Fluoroquinolone antibacterial eye drops: effects on normal human corneal epithelium, stroma, and endothelium

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