Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens

Abstract Ovarian chronic inflammation has been created and extended in the laying hen mainly via increasing laying frequency and microbial infection, especially during the late stage of production period. This study was aimed to evaluate glucocorticoid (GC) Fluticasone as an anti-inflammatory agent...

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Autores principales:	Ali Hatefi, Ahmad Zare Shahneh, Zarbakht Ansari Pirsaraie, Ali Mohammad Alizadeh, Mohammad Pouya Atashnak, Reza Masoudi, Frederic Pio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dec01e8309de4c7782f36dfbebf0d28e
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spelling	oai:doaj.org-article:dec01e8309de4c7782f36dfbebf0d28e2021-11-08T10:51:44ZPro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens10.1038/s41598-021-01141-52045-2322https://doaj.org/article/dec01e8309de4c7782f36dfbebf0d28e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01141-5https://doaj.org/toc/2045-2322Abstract Ovarian chronic inflammation has been created and extended in the laying hen mainly via increasing laying frequency and microbial infection, especially during the late stage of production period. This study was aimed to evaluate glucocorticoid (GC) Fluticasone as an anti-inflammatory agent on the gene expression of the ovarian pro-and anti-inflammatory mediators (follicular cyclooxygenases COX 1, 2, and cytokines), inflammatory responses of the immune system, ovarian functions (ovulation rate and follicular growths), and hormones in the commercial-aged laying hens. White Leghorn hens aged 92-weeks were used for four weeks to be supplemented by 2 ppm Fluticasone as an optimum dose obtained in a pre-trial base on ovulation rate. As compared to control, Fluticasone resulted in a significant decrease in the mRNA expression of COX-1 and pro-and anti-inflammatory cytokines, and increase in COX-2 mRNA expression and heterophil to lymphocyte ratio (P < 0.001). A significant reduction was observed in the ovulation rate, follicular size (P < 0.001), ovarian hormones, immunoglobulins, body weight, and food consummation (P ≤ 0.05) by administering GC Fluticasone. Although a relative anti-inflammatory improvement was created by Fluticasone in the ovarian condition, the administration of this glucocorticoid resulted in a considerable reduction in ovarian hormones and functions of commercial aged laying hens.Ali HatefiAhmad Zare ShahnehZarbakht Ansari PirsaraieAli Mohammad AlizadehMohammad Pouya AtashnakReza MasoudiFrederic PioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ali Hatefi Ahmad Zare Shahneh Zarbakht Ansari Pirsaraie Ali Mohammad Alizadeh Mohammad Pouya Atashnak Reza Masoudi Frederic Pio Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens
description	Abstract Ovarian chronic inflammation has been created and extended in the laying hen mainly via increasing laying frequency and microbial infection, especially during the late stage of production period. This study was aimed to evaluate glucocorticoid (GC) Fluticasone as an anti-inflammatory agent on the gene expression of the ovarian pro-and anti-inflammatory mediators (follicular cyclooxygenases COX 1, 2, and cytokines), inflammatory responses of the immune system, ovarian functions (ovulation rate and follicular growths), and hormones in the commercial-aged laying hens. White Leghorn hens aged 92-weeks were used for four weeks to be supplemented by 2 ppm Fluticasone as an optimum dose obtained in a pre-trial base on ovulation rate. As compared to control, Fluticasone resulted in a significant decrease in the mRNA expression of COX-1 and pro-and anti-inflammatory cytokines, and increase in COX-2 mRNA expression and heterophil to lymphocyte ratio (P < 0.001). A significant reduction was observed in the ovulation rate, follicular size (P < 0.001), ovarian hormones, immunoglobulins, body weight, and food consummation (P ≤ 0.05) by administering GC Fluticasone. Although a relative anti-inflammatory improvement was created by Fluticasone in the ovarian condition, the administration of this glucocorticoid resulted in a considerable reduction in ovarian hormones and functions of commercial aged laying hens.
format	article
author	Ali Hatefi Ahmad Zare Shahneh Zarbakht Ansari Pirsaraie Ali Mohammad Alizadeh Mohammad Pouya Atashnak Reza Masoudi Frederic Pio
author_facet	Ali Hatefi Ahmad Zare Shahneh Zarbakht Ansari Pirsaraie Ali Mohammad Alizadeh Mohammad Pouya Atashnak Reza Masoudi Frederic Pio
author_sort	Ali Hatefi
title	Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens
title_short	Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens
title_full	Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens
title_fullStr	Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens
title_full_unstemmed	Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens
title_sort	pro-and anti-inflammatory effects of glucocorticoid fluticasone on ovarian and immune functions in commercial-aged laying hens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dec01e8309de4c7782f36dfbebf0d28e
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Pro-and anti-inflammatory effects of glucocorticoid Fluticasone on ovarian and immune functions in commercial-aged laying hens

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