Gene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in Transbaikal kray: ethnic and reproductive aspects

The frequency characteristics of gene polymorphisms of MTHFR677T, MTHFR1298C, MTRRA66G that determinate folate metabolism and are associated with perinatal or pregnancy complications were studied in 50 Russian and 50 Buryatyoung healthy women of 19-27 years. The frequency of MTHFR677TT mutant genoty...

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Autores principales:	T. E. Belokrinitskaya, N. I. Frolova, N. N. Strambovskaya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	genic polymorphism methylenetetrahydrofolate reductase methionine synthase reductase ethnic groups Science Q
Acceso en línea:	https://doaj.org/article/dec1731e6f3a448d956499f4a86c7fe6
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spelling	oai:doaj.org-article:dec1731e6f3a448d956499f4a86c7fe62021-11-23T06:14:29ZGene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in Transbaikal kray: ethnic and reproductive aspects2541-94202587-9596https://doaj.org/article/dec1731e6f3a448d956499f4a86c7fe62013-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1631https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The frequency characteristics of gene polymorphisms of MTHFR677T, MTHFR1298C, MTRRA66G that determinate folate metabolism and are associated with perinatal or pregnancy complications were studied in 50 Russian and 50 Buryatyoung healthy women of 19-27 years. The frequency of MTHFR677TT mutant genotype was 6 % (10 % among Russian, 2 % among Buryat women). MTHFR1298CC and MTRR66GG mutant genotypes were detected in 9 % and 31 % respectively without any differences between ethnic groups. Multigenic inheritance of MTHFR677TT and MTH-FR 1298CC, MTHFR677CT and MTRR66AG that multiply increase risks of miscarriage and development of defects of nervous tube of fetus were found only in the group of Russian women (2 %).T. E. BelokrinitskayaN. I. FrolovaN. N. StrambovskayaScientific Сentre for Family Health and Human Reproduction Problemsarticlegenic polymorphismmethylenetetrahydrofolate reductasemethionine synthase reductaseethnic groupsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5, Pp 13-16 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	genic polymorphism methylenetetrahydrofolate reductase methionine synthase reductase ethnic groups Science Q
spellingShingle	genic polymorphism methylenetetrahydrofolate reductase methionine synthase reductase ethnic groups Science Q T. E. Belokrinitskaya N. I. Frolova N. N. Strambovskaya Gene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in Transbaikal kray: ethnic and reproductive aspects
description	The frequency characteristics of gene polymorphisms of MTHFR677T, MTHFR1298C, MTRRA66G that determinate folate metabolism and are associated with perinatal or pregnancy complications were studied in 50 Russian and 50 Buryatyoung healthy women of 19-27 years. The frequency of MTHFR677TT mutant genotype was 6 % (10 % among Russian, 2 % among Buryat women). MTHFR1298CC and MTRR66GG mutant genotypes were detected in 9 % and 31 % respectively without any differences between ethnic groups. Multigenic inheritance of MTHFR677TT and MTH-FR 1298CC, MTHFR677CT and MTRR66AG that multiply increase risks of miscarriage and development of defects of nervous tube of fetus were found only in the group of Russian women (2 %).
format	article
author	T. E. Belokrinitskaya N. I. Frolova N. N. Strambovskaya
author_facet	T. E. Belokrinitskaya N. I. Frolova N. N. Strambovskaya
author_sort	T. E. Belokrinitskaya
title	Gene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in Transbaikal kray: ethnic and reproductive aspects
title_short	Gene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in Transbaikal kray: ethnic and reproductive aspects
title_full	Gene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in Transbaikal kray: ethnic and reproductive aspects
title_fullStr	Gene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in Transbaikal kray: ethnic and reproductive aspects
title_full_unstemmed	Gene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in Transbaikal kray: ethnic and reproductive aspects
title_sort	gene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in transbaikal kray: ethnic and reproductive aspects
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/dec1731e6f3a448d956499f4a86c7fe6
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Gene polymorphism associated with risk of development of homocysteine exchange disorders among young healthy women in Transbaikal kray: ethnic and reproductive aspects

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