A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior

Abstract Postpartum depression is an important mental health issue not only for the mother but also for the child’s development, other family members, and the society. An appropriate animal model is desired to elucidate the pathogenesis of postpartum depression. However, methods for stress loading d...

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Autores principales:	Tomoe Seki, Hirotaka Yamagata, Shusaku Uchida, Ayumi Kobayashi, Yoshifumi Watanabe, Shin Nakagawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dec20e3ed2984838b126d1924e9f72cb
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spelling	oai:doaj.org-article:dec20e3ed2984838b126d1924e9f72cb2021-11-21T12:23:38ZA novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior10.1038/s41598-021-02004-92045-2322https://doaj.org/article/dec20e3ed2984838b126d1924e9f72cb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02004-9https://doaj.org/toc/2045-2322Abstract Postpartum depression is an important mental health issue not only for the mother but also for the child’s development, other family members, and the society. An appropriate animal model is desired to elucidate the pathogenesis of postpartum depression. However, methods for stress loading during pregnancy have not been established. Behavioral experiments to investigate postpartum depression-like behaviors should be conducted without stress because behavioral tests affect rearing behaviors such as lactation. Therefore, we developed a new mouse model of postpartum depression using a psychological stress method. Mating partners were made to witness their partners experiencing social defeat stress and then listen to their cries. Emotional stress loading during pregnancy significantly increased postpartum depression-like behaviors. Postpartum depression also affected nurturing behaviors and caused disturbances in pup care. Furthermore, nesting behavior was impaired in the stressed group, suggesting that the observation of nesting behavior may be useful for assessing social dysfunction in postpartum depression. These results demonstrate the utility of this new mouse model of postpartum depression.Tomoe SekiHirotaka YamagataShusaku UchidaAyumi KobayashiYoshifumi WatanabeShin NakagawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomoe Seki Hirotaka Yamagata Shusaku Uchida Ayumi Kobayashi Yoshifumi Watanabe Shin Nakagawa A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior
description	Abstract Postpartum depression is an important mental health issue not only for the mother but also for the child’s development, other family members, and the society. An appropriate animal model is desired to elucidate the pathogenesis of postpartum depression. However, methods for stress loading during pregnancy have not been established. Behavioral experiments to investigate postpartum depression-like behaviors should be conducted without stress because behavioral tests affect rearing behaviors such as lactation. Therefore, we developed a new mouse model of postpartum depression using a psychological stress method. Mating partners were made to witness their partners experiencing social defeat stress and then listen to their cries. Emotional stress loading during pregnancy significantly increased postpartum depression-like behaviors. Postpartum depression also affected nurturing behaviors and caused disturbances in pup care. Furthermore, nesting behavior was impaired in the stressed group, suggesting that the observation of nesting behavior may be useful for assessing social dysfunction in postpartum depression. These results demonstrate the utility of this new mouse model of postpartum depression.
format	article
author	Tomoe Seki Hirotaka Yamagata Shusaku Uchida Ayumi Kobayashi Yoshifumi Watanabe Shin Nakagawa
author_facet	Tomoe Seki Hirotaka Yamagata Shusaku Uchida Ayumi Kobayashi Yoshifumi Watanabe Shin Nakagawa
author_sort	Tomoe Seki
title	A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior
title_short	A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior
title_full	A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior
title_fullStr	A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior
title_full_unstemmed	A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior
title_sort	novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dec20e3ed2984838b126d1924e9f72cb
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A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior

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