Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation

Caterina Iorio et al. use a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players involved in regulating pancreatic beta cell proliferation. These results suggest that GPR3 and SIK2 are both potential targets to stimulate regeneration of beta cells in diseases like type 1...

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Autores principales:	Caterina Iorio, Jillian L. Rourke, Lisa Wells, Jun-Ichi Sakamaki, Emily Moon, Queenie Hu, Tatsuya Kin, Robert A. Screaton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/dec25cc1168a4f9bbbd67253be002483
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spelling	oai:doaj.org-article:dec25cc1168a4f9bbbd67253be0024832021-12-02T17:03:48ZSilencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation10.1038/s42003-021-02433-22399-3642https://doaj.org/article/dec25cc1168a4f9bbbd67253be0024832021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02433-2https://doaj.org/toc/2399-3642Caterina Iorio et al. use a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players involved in regulating pancreatic beta cell proliferation. These results suggest that GPR3 and SIK2 are both potential targets to stimulate regeneration of beta cells in diseases like type 1 diabetes.Caterina IorioJillian L. RourkeLisa WellsJun-Ichi SakamakiEmily MoonQueenie HuTatsuya KinRobert A. ScreatonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Caterina Iorio Jillian L. Rourke Lisa Wells Jun-Ichi Sakamaki Emily Moon Queenie Hu Tatsuya Kin Robert A. Screaton Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
description	Caterina Iorio et al. use a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players involved in regulating pancreatic beta cell proliferation. These results suggest that GPR3 and SIK2 are both potential targets to stimulate regeneration of beta cells in diseases like type 1 diabetes.
format	article
author	Caterina Iorio Jillian L. Rourke Lisa Wells Jun-Ichi Sakamaki Emily Moon Queenie Hu Tatsuya Kin Robert A. Screaton
author_facet	Caterina Iorio Jillian L. Rourke Lisa Wells Jun-Ichi Sakamaki Emily Moon Queenie Hu Tatsuya Kin Robert A. Screaton
author_sort	Caterina Iorio
title	Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_short	Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_full	Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_fullStr	Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_full_unstemmed	Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
title_sort	silencing the g-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dec25cc1168a4f9bbbd67253be002483
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Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation

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