Avitene™ Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review

David J Cziperle Thoracic Surgery, Ann B. Barshinger Cancer Institute, Lancaster, PA, USACorrespondence: David J CziperleThoracic Surgery, Ann B. Barshinger Cancer Institiute, 2102 Harrisburg Pike, Lancaster, PA, 17601, USATel +1-717-544-9400Fax +1-717-544-9401Email david.cziperle@pennmedicine.upenn...

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Autor principal:	Cziperle DJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	avitene hemostasis surgery topical hemorrhage microfibrillar collagen Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/dec70cd2d61f4992bd838df5bf39c2ac
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spelling	oai:doaj.org-article:dec70cd2d61f4992bd838df5bf39c2ac2021-12-02T14:39:27ZAvitene™ Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review1179-1470https://doaj.org/article/dec70cd2d61f4992bd838df5bf39c2ac2021-06-01T00:00:00Zhttps://www.dovepress.com/avitene-microfibrillar-collagen-hemostat-for-adjunctive-hemostasis-in--peer-reviewed-fulltext-article-MDERhttps://doaj.org/toc/1179-1470David J Cziperle Thoracic Surgery, Ann B. Barshinger Cancer Institute, Lancaster, PA, USACorrespondence: David J CziperleThoracic Surgery, Ann B. Barshinger Cancer Institiute, 2102 Harrisburg Pike, Lancaster, PA, 17601, USATel +1-717-544-9400Fax +1-717-544-9401Email david.cziperle@pennmedicine.upenn.eduAbstract: Adequate hemostasis during surgical procedures is essential for successful patient outcomes and reduced healthcare resource utilization. Topical hemostatic agents can act as catalysts for the clotting cascade or as a scaffold to promote platelet activation or aggregation. Although an ever-increasing number of topical absorbable hemostatic agents are now available for perioperative use, health care providers are disadvantaged by the lack of comparative data on feasibility, clinical effectiveness, advantages, and limitations of each in specific surgical settings. This knowledge is important for appropriate product choice when patient characteristics, type of surgical procedure, type of bleeding, and product availability may differ widely. This manuscript provides the first comprehensive overview of Avitene™ Microfibrillar Collagen Hemostat (MCH), a bovine collagen-based absorbable hemostat that has been widely used for over four decades in the United States and abroad. MCH is indicated as an adjunct to hemostasis across a broad spectrum of surgical specialties and has been shown to achieve hemostasis with positive patient outcomes and a favorable safety profile in many applications, including hepatic, orthopedic, splenic, oral, and otolaryngologic surgery. Although published clinical data regarding the use of MCH in cardiovascular surgery is limited, evidence suggests moderate use in this specialty. The information contained in this systematic review will help health care providers understand the clinical use and effectiveness of the product to determine appropriate use in differing bleeding scenarios across multiple surgical specialties. Future studies may include comparative functional and cost analyses to explore the economic advantages of using absorbable hemostatic agents compared with each other or with conventional techniques of hemostasis, when appropriate.Keywords: Avitene, hemostasis, surgery, topical, hemorrhage, microfibrillar collagenCziperle DJDove Medical Pressarticleavitenehemostasissurgerytopicalhemorrhagemicrofibrillar collagenMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol Volume 14, Pp 155-163 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	avitene hemostasis surgery topical hemorrhage microfibrillar collagen Medical technology R855-855.5
spellingShingle	avitene hemostasis surgery topical hemorrhage microfibrillar collagen Medical technology R855-855.5 Cziperle DJ Avitene™ Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review
description	David J Cziperle Thoracic Surgery, Ann B. Barshinger Cancer Institute, Lancaster, PA, USACorrespondence: David J CziperleThoracic Surgery, Ann B. Barshinger Cancer Institiute, 2102 Harrisburg Pike, Lancaster, PA, 17601, USATel +1-717-544-9400Fax +1-717-544-9401Email david.cziperle@pennmedicine.upenn.eduAbstract: Adequate hemostasis during surgical procedures is essential for successful patient outcomes and reduced healthcare resource utilization. Topical hemostatic agents can act as catalysts for the clotting cascade or as a scaffold to promote platelet activation or aggregation. Although an ever-increasing number of topical absorbable hemostatic agents are now available for perioperative use, health care providers are disadvantaged by the lack of comparative data on feasibility, clinical effectiveness, advantages, and limitations of each in specific surgical settings. This knowledge is important for appropriate product choice when patient characteristics, type of surgical procedure, type of bleeding, and product availability may differ widely. This manuscript provides the first comprehensive overview of Avitene™ Microfibrillar Collagen Hemostat (MCH), a bovine collagen-based absorbable hemostat that has been widely used for over four decades in the United States and abroad. MCH is indicated as an adjunct to hemostasis across a broad spectrum of surgical specialties and has been shown to achieve hemostasis with positive patient outcomes and a favorable safety profile in many applications, including hepatic, orthopedic, splenic, oral, and otolaryngologic surgery. Although published clinical data regarding the use of MCH in cardiovascular surgery is limited, evidence suggests moderate use in this specialty. The information contained in this systematic review will help health care providers understand the clinical use and effectiveness of the product to determine appropriate use in differing bleeding scenarios across multiple surgical specialties. Future studies may include comparative functional and cost analyses to explore the economic advantages of using absorbable hemostatic agents compared with each other or with conventional techniques of hemostasis, when appropriate.Keywords: Avitene, hemostasis, surgery, topical, hemorrhage, microfibrillar collagen
format	article
author	Cziperle DJ
author_facet	Cziperle DJ
author_sort	Cziperle DJ
title	Avitene™ Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review
title_short	Avitene™ Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review
title_full	Avitene™ Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review
title_fullStr	Avitene™ Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review
title_full_unstemmed	Avitene™ Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review
title_sort	avitene™ microfibrillar collagen hemostat for adjunctive hemostasis in surgical procedures: a systematic literature review
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/dec70cd2d61f4992bd838df5bf39c2ac
work_keys_str_mv	AT cziperledj avitenetrademicrofibrillarcollagenhemostatforadjunctivehemostasisinsurgicalproceduresasystematicliteraturereview
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Avitene&trade; Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review

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Avitene™ Microfibrillar Collagen Hemostat for Adjunctive Hemostasis in Surgical Procedures: A Systematic Literature Review