Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity....

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Autores principales: Carine Z. J. Lim, Yan Zhang, Yu Chen, Haitao Zhao, Mary C. Stephenson, Nicholas R. Y. Ho, Yuan Chen, Jaehoon Chung, Anthonin Reilhac, Tze Ping Loh, Christopher L. H. Chen, Huilin Shao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/dec9dff033f84a82beaf5f86c984fcd5
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Sumario:Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity.