Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity....

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Autores principales:	Carine Z. J. Lim, Yan Zhang, Yu Chen, Haitao Zhao, Mary C. Stephenson, Nicholas R. Y. Ho, Yuan Chen, Jaehoon Chung, Anthonin Reilhac, Tze Ping Loh, Christopher L. H. Chen, Huilin Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dec9dff033f84a82beaf5f86c984fcd5
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spelling	oai:doaj.org-article:dec9dff033f84a82beaf5f86c984fcd52021-12-02T14:39:18ZSubtyping of circulating exosome-bound amyloid β reflects brain plaque deposition10.1038/s41467-019-09030-22041-1723https://doaj.org/article/dec9dff033f84a82beaf5f86c984fcd52019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09030-2https://doaj.org/toc/2041-1723Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity.Carine Z. J. LimYan ZhangYu ChenHaitao ZhaoMary C. StephensonNicholas R. Y. HoYuan ChenJaehoon ChungAnthonin ReilhacTze Ping LohChristopher L. H. ChenHuilin ShaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carine Z. J. Lim Yan Zhang Yu Chen Haitao Zhao Mary C. Stephenson Nicholas R. Y. Ho Yuan Chen Jaehoon Chung Anthonin Reilhac Tze Ping Loh Christopher L. H. Chen Huilin Shao Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
description	Detecting Alzheimer’s disease from blood samples is challenging because amyloid β blood levels are lower than the ELISA detection limit. Here the authors capture amyloid β bound to circulating exosomes on a plasmonic nanosensor, followed by enzymatic amplification to improve detection sensitivity.
format	article
author	Carine Z. J. Lim Yan Zhang Yu Chen Haitao Zhao Mary C. Stephenson Nicholas R. Y. Ho Yuan Chen Jaehoon Chung Anthonin Reilhac Tze Ping Loh Christopher L. H. Chen Huilin Shao
author_facet	Carine Z. J. Lim Yan Zhang Yu Chen Haitao Zhao Mary C. Stephenson Nicholas R. Y. Ho Yuan Chen Jaehoon Chung Anthonin Reilhac Tze Ping Loh Christopher L. H. Chen Huilin Shao
author_sort	Carine Z. J. Lim
title	Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
title_short	Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
title_full	Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
title_fullStr	Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
title_full_unstemmed	Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
title_sort	subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/dec9dff033f84a82beaf5f86c984fcd5
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Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

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