Population-Based Study on the All-Cause and Cause-Specific Risks of Mortality among Long-Term Opioid Analgesics Users without Cancer in Taiwan

(1) Background: The prevalence of opioid use in Taiwan increased by 41% between 2002 and 2014. However, little is known regarding the risk of mortality among long-term opioid analgesics users who do not have cancer. This study investigated this mortality risk with an emphasis on the calendar year an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Po-Feng Lee, Chung-Yi Li, Yen-Chin Liu, Chang-Ta Chiu, Wen-Hsuan Hou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prescription opioids mortality standardized mortality ratio underlying cause of death Medicine R
Acceso en línea:	https://doaj.org/article/deca200fcdee4ca48da350d1c854e03d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:deca200fcdee4ca48da350d1c854e03d
record_format	dspace
spelling	oai:doaj.org-article:deca200fcdee4ca48da350d1c854e03d2021-11-25T17:43:26ZPopulation-Based Study on the All-Cause and Cause-Specific Risks of Mortality among Long-Term Opioid Analgesics Users without Cancer in Taiwan10.3390/healthcare91114022227-9032https://doaj.org/article/deca200fcdee4ca48da350d1c854e03d2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1402https://doaj.org/toc/2227-9032(1) Background: The prevalence of opioid use in Taiwan increased by 41% between 2002 and 2014. However, little is known regarding the risk of mortality among long-term opioid analgesics users who do not have cancer. This study investigated this mortality risk with an emphasis on the calendar year and patients’ age and sex. (2) Methods: This retrospective cohort study included 12,990 adult individuals without cancer who were long-term users of opioid analgesics and were randomly selected from the data set of Taiwan’s National Health Insurance program from 2000 to 2012. They were then followed up through 2013. Information on the underlying causes of death was retrieved from the Taiwan Death Registry. Age, sex, and calendar year-standardized mortality ratios (SMRs) of all-cause and cause-specific mortality were calculated with reference to those of the general population. (3) Results: With up to 14 years of follow-up, 558 individuals had all-cause mortality in 48,020 person-years (cumulative mortality: 4.3%, mortality rate: 11.62 per 1000 person-years). Compared with the general population, the all-cause SMR of 4.30 (95% confidence interval (95% CI): 3.95–4.66) was significantly higher: it was higher in men than in women, declined with calendar year and age, and was significantly higher for both natural (4.15, 95% CI: 3.78–4.53) and unnatural (5.04, 95% CI: 3.88–6.45) causes. (4) Conclusions: Long-term opioid analgesics use among individuals without cancer in Taiwan was associated with a significantly increased risk of mortality. The notably increased mortality in younger adults warrants attention. Strategies to reduce long-term opioid analgesics use, especially their overuse or misuse, are in an urgent need.Po-Feng LeeChung-Yi LiYen-Chin LiuChang-Ta ChiuWen-Hsuan HouMDPI AGarticleprescription opioidsmortalitystandardized mortality ratiounderlying cause of deathMedicineRENHealthcare, Vol 9, Iss 1402, p 1402 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prescription opioids mortality standardized mortality ratio underlying cause of death Medicine R
spellingShingle	prescription opioids mortality standardized mortality ratio underlying cause of death Medicine R Po-Feng Lee Chung-Yi Li Yen-Chin Liu Chang-Ta Chiu Wen-Hsuan Hou Population-Based Study on the All-Cause and Cause-Specific Risks of Mortality among Long-Term Opioid Analgesics Users without Cancer in Taiwan
description	(1) Background: The prevalence of opioid use in Taiwan increased by 41% between 2002 and 2014. However, little is known regarding the risk of mortality among long-term opioid analgesics users who do not have cancer. This study investigated this mortality risk with an emphasis on the calendar year and patients’ age and sex. (2) Methods: This retrospective cohort study included 12,990 adult individuals without cancer who were long-term users of opioid analgesics and were randomly selected from the data set of Taiwan’s National Health Insurance program from 2000 to 2012. They were then followed up through 2013. Information on the underlying causes of death was retrieved from the Taiwan Death Registry. Age, sex, and calendar year-standardized mortality ratios (SMRs) of all-cause and cause-specific mortality were calculated with reference to those of the general population. (3) Results: With up to 14 years of follow-up, 558 individuals had all-cause mortality in 48,020 person-years (cumulative mortality: 4.3%, mortality rate: 11.62 per 1000 person-years). Compared with the general population, the all-cause SMR of 4.30 (95% confidence interval (95% CI): 3.95–4.66) was significantly higher: it was higher in men than in women, declined with calendar year and age, and was significantly higher for both natural (4.15, 95% CI: 3.78–4.53) and unnatural (5.04, 95% CI: 3.88–6.45) causes. (4) Conclusions: Long-term opioid analgesics use among individuals without cancer in Taiwan was associated with a significantly increased risk of mortality. The notably increased mortality in younger adults warrants attention. Strategies to reduce long-term opioid analgesics use, especially their overuse or misuse, are in an urgent need.
format	article
author	Po-Feng Lee Chung-Yi Li Yen-Chin Liu Chang-Ta Chiu Wen-Hsuan Hou
author_facet	Po-Feng Lee Chung-Yi Li Yen-Chin Liu Chang-Ta Chiu Wen-Hsuan Hou
author_sort	Po-Feng Lee
title	Population-Based Study on the All-Cause and Cause-Specific Risks of Mortality among Long-Term Opioid Analgesics Users without Cancer in Taiwan
title_short	Population-Based Study on the All-Cause and Cause-Specific Risks of Mortality among Long-Term Opioid Analgesics Users without Cancer in Taiwan
title_full	Population-Based Study on the All-Cause and Cause-Specific Risks of Mortality among Long-Term Opioid Analgesics Users without Cancer in Taiwan
title_fullStr	Population-Based Study on the All-Cause and Cause-Specific Risks of Mortality among Long-Term Opioid Analgesics Users without Cancer in Taiwan
title_full_unstemmed	Population-Based Study on the All-Cause and Cause-Specific Risks of Mortality among Long-Term Opioid Analgesics Users without Cancer in Taiwan
title_sort	population-based study on the all-cause and cause-specific risks of mortality among long-term opioid analgesics users without cancer in taiwan
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/deca200fcdee4ca48da350d1c854e03d
work_keys_str_mv	AT pofenglee populationbasedstudyontheallcauseandcausespecificrisksofmortalityamonglongtermopioidanalgesicsuserswithoutcancerintaiwan AT chungyili populationbasedstudyontheallcauseandcausespecificrisksofmortalityamonglongtermopioidanalgesicsuserswithoutcancerintaiwan AT yenchinliu populationbasedstudyontheallcauseandcausespecificrisksofmortalityamonglongtermopioidanalgesicsuserswithoutcancerintaiwan AT changtachiu populationbasedstudyontheallcauseandcausespecificrisksofmortalityamonglongtermopioidanalgesicsuserswithoutcancerintaiwan AT wenhsuanhou populationbasedstudyontheallcauseandcausespecificrisksofmortalityamonglongtermopioidanalgesicsuserswithoutcancerintaiwan
_version_	1718412076802637824

Population-Based Study on the All-Cause and Cause-Specific Risks of Mortality among Long-Term Opioid Analgesics Users without Cancer in Taiwan

Ejemplares similares