New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

A genome-wide association meta-analysis study here shows novel genetic loci to be associated to body fat percentage, and describes cross-phenotype association that further demonstrate a close relationship between adiposity and cardiovascular disease risk.

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Autores principales:	Yingchang Lu, Felix R. Day, Stefan Gustafsson, Martin L. Buchkovich, Jianbo Na, Veronique Bataille, Diana L. Cousminer, Zari Dastani, Alexander W. Drong, Tõnu Esko, David M. Evans, Mario Falchi, Mary F. Feitosa, Teresa Ferreira, Åsa K. Hedman, Robin Haring, Pirro G. Hysi, Mark M. Iles, Anne E. Justice, Stavroula Kanoni, Vasiliki Lagou, Rui Li, Xin Li, Adam Locke, Chen Lu, Reedik Mägi, John R. B. Perry, Tune H. Pers, Qibin Qi, Marianna Sanna, Ellen M. Schmidt, William R. Scott, Dmitry Shungin, Alexander Teumer, Anna A. E. Vinkhuyzen, Ryan W. Walker, Harm-Jan Westra, Mingfeng Zhang, Weihua Zhang, Jing Hua Zhao, Zhihong Zhu, Uzma Afzal, Tarunveer Singh Ahluwalia, Stephan J. L. Bakker, Claire Bellis, Amélie Bonnefond, Katja Borodulin, Aron S. Buchman, Tommy Cederholm, Audrey C. Choh, Hyung Jin Choi, Joanne E. Curran, Lisette C. P. G. M. de Groot, Philip L. De Jager, Rosalie A. M. Dhonukshe-Rutten, Anke W. Enneman, Elodie Eury, Daniel S. Evans, Tom Forsen, Nele Friedrich, Frédéric Fumeron, Melissa E. Garcia, Simone Gärtner, Bok-Ghee Han, Aki S. Havulinna, Caroline Hayward, Dena Hernandez, Hans Hillege, Till Ittermann, Jack W. Kent, Ivana Kolcic, Tiina Laatikainen, Jari Lahti, Irene Mateo Leach, Christine G. Lee, Jong-Young Lee, Tian Liu, Youfang Liu, Stéphane Lobbens, Marie Loh, Leo-Pekka Lyytikäinen, Carolina Medina-Gomez, Karl Michaëlsson, Mike A. Nalls, Carrie M. Nielson, Laticia Oozageer, Laura Pascoe, Lavinia Paternoster, Ozren Polašek, Samuli Ripatti, Mark A. Sarzynski, Chan Soo Shin, Nina Smolej Narančić, Dominik Spira, Priya Srikanth, Elisabeth Steinhagen-Thiessen, Yun Ju Sung, Karin M. A. Swart, Leena Taittonen, Toshiko Tanaka, Emmi Tikkanen, Nathalie van der Velde, Natasja M. van Schoor, Niek Verweij, Alan F. Wright, Lei Yu, Joseph M. Zmuda, Niina Eklund, Terrence Forrester, Niels Grarup, Anne U. Jackson, Kati Kristiansson, Teemu Kuulasmaa, Johanna Kuusisto, Peter Lichtner, Jian'an Luan, Anubha Mahajan, Satu Männistö, Cameron D. Palmer, Janina S. Ried, Robert A. Scott, Alena Stancáková, Peter J. Wagner, Ayse Demirkan, Angela Döring, Vilmundur Gudnason, Douglas P. Kiel, Brigitte Kühnel, Massimo Mangino, Barbara Mcknight, Cristina Menni, Jeffrey R. O'Connell, Ben A. Oostra, Alan R. Shuldiner, Kijoung Song, Liesbeth Vandenput, Cornelia M. van Duijn, Peter Vollenweider, Charles C. White, Michael Boehnke, Yvonne Boettcher, Richard S. Cooper, Nita G. Forouhi, Christian Gieger, Harald Grallert, Aroon Hingorani, Torben Jørgensen, Pekka Jousilahti, Mika Kivimaki, Meena Kumari, Markku Laakso, Claudia Langenberg, Allan Linneberg, Amy Luke, Colin A. Mckenzie, Aarno Palotie, Oluf Pedersen, Annette Peters, Konstantin Strauch, Bamidele O. Tayo, Nicholas J. Wareham, David A. Bennett, Lars Bertram, John Blangero, Matthias Blüher, Claude Bouchard, Harry Campbell, Nam H. Cho, Steven R. Cummings, Stefan A. Czerwinski, Ilja Demuth, Rahel Eckardt, Johan G. Eriksson, Luigi Ferrucci, Oscar H. Franco, Philippe Froguel, Ron T. Gansevoort, Torben Hansen, Tamara B. Harris, Nicholas Hastie, Markku Heliövaara, Albert Hofman, Joanne M. Jordan, Antti Jula, Mika Kähönen, Eero Kajantie, Paul B. Knekt, Seppo Koskinen, Peter Kovacs, Terho Lehtimäki, Lars Lind, Yongmei Liu, Eric S. Orwoll, Clive Osmond, Markus Perola, Louis Pérusse, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Treva K. Rice, Fernando Rivadeneira, Igor Rudan, Veikko Salomaa, Thorkild I. A. Sørensen, Michael Stumvoll, Anke Tönjes, Bradford Towne, Gregory J. Tranah, Angelo Tremblay, André G. Uitterlinden, Pim van der Harst, Erkki Vartiainen, Jorma S. Viikari, Veronique Vitart, Marie-Claude Vohl, Henry Völzke, Mark Walker, Henri Wallaschofski, Sarah Wild, James F. Wilson, Loïc Yengo, D. Timothy Bishop, Ingrid B. Borecki, John C. Chambers, L. Adrienne Cupples, Abbas Dehghan, Panos Deloukas, Ghazaleh Fatemifar, Caroline Fox, Terrence S. Furey, Lude Franke, Jiali Han, David J. Hunter, Juha Karjalainen, Fredrik Karpe, Robert C. Kaplan, Jaspal S. Kooner, Mark I. McCarthy, Joanne M. Murabito, Andrew P. Morris, Julia A. N. Bishop, Kari E. North, Claes Ohlsson, Ken K. Ong, Inga Prokopenko, J. Brent Richards, Eric E. Schadt, Tim D. Spector, Elisabeth Widén, Cristen J. Willer, Jian Yang, Erik Ingelsson, Karen L. Mohlke, Joel N. Hirschhorn, John Andrew Pospisilik, M. Carola Zillikens, Cecilia Lindgren, Tuomas Oskari Kilpeläinen, Ruth J. F. Loos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dece01483ac84fdb93ab7a953a7205a9
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record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingchang Lu Felix R. Day Stefan Gustafsson Martin L. Buchkovich Jianbo Na Veronique Bataille Diana L. Cousminer Zari Dastani Alexander W. Drong Tõnu Esko David M. Evans Mario Falchi Mary F. Feitosa Teresa Ferreira Åsa K. Hedman Robin Haring Pirro G. Hysi Mark M. Iles Anne E. Justice Stavroula Kanoni Vasiliki Lagou Rui Li Xin Li Adam Locke Chen Lu Reedik Mägi John R. B. Perry Tune H. Pers Qibin Qi Marianna Sanna Ellen M. Schmidt William R. Scott Dmitry Shungin Alexander Teumer Anna A. E. Vinkhuyzen Ryan W. Walker Harm-Jan Westra Mingfeng Zhang Weihua Zhang Jing Hua Zhao Zhihong Zhu Uzma Afzal Tarunveer Singh Ahluwalia Stephan J. L. Bakker Claire Bellis Amélie Bonnefond Katja Borodulin Aron S. Buchman Tommy Cederholm Audrey C. Choh Hyung Jin Choi Joanne E. Curran Lisette C. P. G. M. de Groot Philip L. De Jager Rosalie A. M. Dhonukshe-Rutten Anke W. Enneman Elodie Eury Daniel S. Evans Tom Forsen Nele Friedrich Frédéric Fumeron Melissa E. Garcia Simone Gärtner Bok-Ghee Han Aki S. Havulinna Caroline Hayward Dena Hernandez Hans Hillege Till Ittermann Jack W. Kent Ivana Kolcic Tiina Laatikainen Jari Lahti Irene Mateo Leach Christine G. Lee Jong-Young Lee Tian Liu Youfang Liu Stéphane Lobbens Marie Loh Leo-Pekka Lyytikäinen Carolina Medina-Gomez Karl Michaëlsson Mike A. Nalls Carrie M. Nielson Laticia Oozageer Laura Pascoe Lavinia Paternoster Ozren Polašek Samuli Ripatti Mark A. Sarzynski Chan Soo Shin Nina Smolej Narančić Dominik Spira Priya Srikanth Elisabeth Steinhagen-Thiessen Yun Ju Sung Karin M. A. Swart Leena Taittonen Toshiko Tanaka Emmi Tikkanen Nathalie van der Velde Natasja M. van Schoor Niek Verweij Alan F. Wright Lei Yu Joseph M. Zmuda Niina Eklund Terrence Forrester Niels Grarup Anne U. Jackson Kati Kristiansson Teemu Kuulasmaa Johanna Kuusisto Peter Lichtner Jian'an Luan Anubha Mahajan Satu Männistö Cameron D. Palmer Janina S. Ried Robert A. Scott Alena Stancáková Peter J. Wagner Ayse Demirkan Angela Döring Vilmundur Gudnason Douglas P. Kiel Brigitte Kühnel Massimo Mangino Barbara Mcknight Cristina Menni Jeffrey R. O'Connell Ben A. Oostra Alan R. Shuldiner Kijoung Song Liesbeth Vandenput Cornelia M. van Duijn Peter Vollenweider Charles C. White Michael Boehnke Yvonne Boettcher Richard S. Cooper Nita G. Forouhi Christian Gieger Harald Grallert Aroon Hingorani Torben Jørgensen Pekka Jousilahti Mika Kivimaki Meena Kumari Markku Laakso Claudia Langenberg Allan Linneberg Amy Luke Colin A. Mckenzie Aarno Palotie Oluf Pedersen Annette Peters Konstantin Strauch Bamidele O. Tayo Nicholas J. Wareham David A. Bennett Lars Bertram John Blangero Matthias Blüher Claude Bouchard Harry Campbell Nam H. Cho Steven R. Cummings Stefan A. Czerwinski Ilja Demuth Rahel Eckardt Johan G. Eriksson Luigi Ferrucci Oscar H. Franco Philippe Froguel Ron T. Gansevoort Torben Hansen Tamara B. Harris Nicholas Hastie Markku Heliövaara Albert Hofman Joanne M. Jordan Antti Jula Mika Kähönen Eero Kajantie Paul B. Knekt Seppo Koskinen Peter Kovacs Terho Lehtimäki Lars Lind Yongmei Liu Eric S. Orwoll Clive Osmond Markus Perola Louis Pérusse Olli T. Raitakari Tuomo Rankinen D. C. Rao Treva K. Rice Fernando Rivadeneira Igor Rudan Veikko Salomaa Thorkild I. A. Sørensen Michael Stumvoll Anke Tönjes Bradford Towne Gregory J. Tranah Angelo Tremblay André G. Uitterlinden Pim van der Harst Erkki Vartiainen Jorma S. Viikari Veronique Vitart Marie-Claude Vohl Henry Völzke Mark Walker Henri Wallaschofski Sarah Wild James F. Wilson Loïc Yengo D. Timothy Bishop Ingrid B. Borecki John C. Chambers L. Adrienne Cupples Abbas Dehghan Panos Deloukas Ghazaleh Fatemifar Caroline Fox Terrence S. Furey Lude Franke Jiali Han David J. Hunter Juha Karjalainen Fredrik Karpe Robert C. Kaplan Jaspal S. Kooner Mark I. McCarthy Joanne M. Murabito Andrew P. Morris Julia A. N. Bishop Kari E. North Claes Ohlsson Ken K. Ong Inga Prokopenko J. Brent Richards Eric E. Schadt Tim D. Spector Elisabeth Widén Cristen J. Willer Jian Yang Erik Ingelsson Karen L. Mohlke Joel N. Hirschhorn John Andrew Pospisilik M. Carola Zillikens Cecilia Lindgren Tuomas Oskari Kilpeläinen Ruth J. F. Loos New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
description	A genome-wide association meta-analysis study here shows novel genetic loci to be associated to body fat percentage, and describes cross-phenotype association that further demonstrate a close relationship between adiposity and cardiovascular disease risk.
format	article
author	Yingchang Lu Felix R. Day Stefan Gustafsson Martin L. Buchkovich Jianbo Na Veronique Bataille Diana L. Cousminer Zari Dastani Alexander W. Drong Tõnu Esko David M. Evans Mario Falchi Mary F. Feitosa Teresa Ferreira Åsa K. Hedman Robin Haring Pirro G. Hysi Mark M. Iles Anne E. Justice Stavroula Kanoni Vasiliki Lagou Rui Li Xin Li Adam Locke Chen Lu Reedik Mägi John R. B. Perry Tune H. Pers Qibin Qi Marianna Sanna Ellen M. Schmidt William R. Scott Dmitry Shungin Alexander Teumer Anna A. E. Vinkhuyzen Ryan W. Walker Harm-Jan Westra Mingfeng Zhang Weihua Zhang Jing Hua Zhao Zhihong Zhu Uzma Afzal Tarunveer Singh Ahluwalia Stephan J. L. Bakker Claire Bellis Amélie Bonnefond Katja Borodulin Aron S. Buchman Tommy Cederholm Audrey C. Choh Hyung Jin Choi Joanne E. Curran Lisette C. P. G. M. de Groot Philip L. De Jager Rosalie A. M. Dhonukshe-Rutten Anke W. Enneman Elodie Eury Daniel S. Evans Tom Forsen Nele Friedrich Frédéric Fumeron Melissa E. Garcia Simone Gärtner Bok-Ghee Han Aki S. Havulinna Caroline Hayward Dena Hernandez Hans Hillege Till Ittermann Jack W. Kent Ivana Kolcic Tiina Laatikainen Jari Lahti Irene Mateo Leach Christine G. Lee Jong-Young Lee Tian Liu Youfang Liu Stéphane Lobbens Marie Loh Leo-Pekka Lyytikäinen Carolina Medina-Gomez Karl Michaëlsson Mike A. Nalls Carrie M. Nielson Laticia Oozageer Laura Pascoe Lavinia Paternoster Ozren Polašek Samuli Ripatti Mark A. Sarzynski Chan Soo Shin Nina Smolej Narančić Dominik Spira Priya Srikanth Elisabeth Steinhagen-Thiessen Yun Ju Sung Karin M. A. Swart Leena Taittonen Toshiko Tanaka Emmi Tikkanen Nathalie van der Velde Natasja M. van Schoor Niek Verweij Alan F. Wright Lei Yu Joseph M. Zmuda Niina Eklund Terrence Forrester Niels Grarup Anne U. Jackson Kati Kristiansson Teemu Kuulasmaa Johanna Kuusisto Peter Lichtner Jian'an Luan Anubha Mahajan Satu Männistö Cameron D. Palmer Janina S. Ried Robert A. Scott Alena Stancáková Peter J. Wagner Ayse Demirkan Angela Döring Vilmundur Gudnason Douglas P. Kiel Brigitte Kühnel Massimo Mangino Barbara Mcknight Cristina Menni Jeffrey R. O'Connell Ben A. Oostra Alan R. Shuldiner Kijoung Song Liesbeth Vandenput Cornelia M. van Duijn Peter Vollenweider Charles C. White Michael Boehnke Yvonne Boettcher Richard S. Cooper Nita G. Forouhi Christian Gieger Harald Grallert Aroon Hingorani Torben Jørgensen Pekka Jousilahti Mika Kivimaki Meena Kumari Markku Laakso Claudia Langenberg Allan Linneberg Amy Luke Colin A. Mckenzie Aarno Palotie Oluf Pedersen Annette Peters Konstantin Strauch Bamidele O. Tayo Nicholas J. Wareham David A. Bennett Lars Bertram John Blangero Matthias Blüher Claude Bouchard Harry Campbell Nam H. Cho Steven R. Cummings Stefan A. Czerwinski Ilja Demuth Rahel Eckardt Johan G. Eriksson Luigi Ferrucci Oscar H. Franco Philippe Froguel Ron T. Gansevoort Torben Hansen Tamara B. Harris Nicholas Hastie Markku Heliövaara Albert Hofman Joanne M. Jordan Antti Jula Mika Kähönen Eero Kajantie Paul B. Knekt Seppo Koskinen Peter Kovacs Terho Lehtimäki Lars Lind Yongmei Liu Eric S. Orwoll Clive Osmond Markus Perola Louis Pérusse Olli T. Raitakari Tuomo Rankinen D. C. Rao Treva K. Rice Fernando Rivadeneira Igor Rudan Veikko Salomaa Thorkild I. A. Sørensen Michael Stumvoll Anke Tönjes Bradford Towne Gregory J. Tranah Angelo Tremblay André G. Uitterlinden Pim van der Harst Erkki Vartiainen Jorma S. Viikari Veronique Vitart Marie-Claude Vohl Henry Völzke Mark Walker Henri Wallaschofski Sarah Wild James F. Wilson Loïc Yengo D. Timothy Bishop Ingrid B. Borecki John C. Chambers L. Adrienne Cupples Abbas Dehghan Panos Deloukas Ghazaleh Fatemifar Caroline Fox Terrence S. Furey Lude Franke Jiali Han David J. Hunter Juha Karjalainen Fredrik Karpe Robert C. Kaplan Jaspal S. Kooner Mark I. McCarthy Joanne M. Murabito Andrew P. Morris Julia A. N. Bishop Kari E. North Claes Ohlsson Ken K. Ong Inga Prokopenko J. Brent Richards Eric E. Schadt Tim D. Spector Elisabeth Widén Cristen J. Willer Jian Yang Erik Ingelsson Karen L. Mohlke Joel N. Hirschhorn John Andrew Pospisilik M. Carola Zillikens Cecilia Lindgren Tuomas Oskari Kilpeläinen Ruth J. F. Loos
author_facet	Yingchang Lu Felix R. Day Stefan Gustafsson Martin L. Buchkovich Jianbo Na Veronique Bataille Diana L. Cousminer Zari Dastani Alexander W. Drong Tõnu Esko David M. Evans Mario Falchi Mary F. Feitosa Teresa Ferreira Åsa K. Hedman Robin Haring Pirro G. Hysi Mark M. Iles Anne E. Justice Stavroula Kanoni Vasiliki Lagou Rui Li Xin Li Adam Locke Chen Lu Reedik Mägi John R. B. Perry Tune H. Pers Qibin Qi Marianna Sanna Ellen M. Schmidt William R. Scott Dmitry Shungin Alexander Teumer Anna A. E. Vinkhuyzen Ryan W. Walker Harm-Jan Westra Mingfeng Zhang Weihua Zhang Jing Hua Zhao Zhihong Zhu Uzma Afzal Tarunveer Singh Ahluwalia Stephan J. L. Bakker Claire Bellis Amélie Bonnefond Katja Borodulin Aron S. Buchman Tommy Cederholm Audrey C. Choh Hyung Jin Choi Joanne E. Curran Lisette C. P. G. M. de Groot Philip L. De Jager Rosalie A. M. Dhonukshe-Rutten Anke W. Enneman Elodie Eury Daniel S. Evans Tom Forsen Nele Friedrich Frédéric Fumeron Melissa E. Garcia Simone Gärtner Bok-Ghee Han Aki S. Havulinna Caroline Hayward Dena Hernandez Hans Hillege Till Ittermann Jack W. Kent Ivana Kolcic Tiina Laatikainen Jari Lahti Irene Mateo Leach Christine G. Lee Jong-Young Lee Tian Liu Youfang Liu Stéphane Lobbens Marie Loh Leo-Pekka Lyytikäinen Carolina Medina-Gomez Karl Michaëlsson Mike A. Nalls Carrie M. Nielson Laticia Oozageer Laura Pascoe Lavinia Paternoster Ozren Polašek Samuli Ripatti Mark A. Sarzynski Chan Soo Shin Nina Smolej Narančić Dominik Spira Priya Srikanth Elisabeth Steinhagen-Thiessen Yun Ju Sung Karin M. A. Swart Leena Taittonen Toshiko Tanaka Emmi Tikkanen Nathalie van der Velde Natasja M. van Schoor Niek Verweij Alan F. Wright Lei Yu Joseph M. Zmuda Niina Eklund Terrence Forrester Niels Grarup Anne U. Jackson Kati Kristiansson Teemu Kuulasmaa Johanna Kuusisto Peter Lichtner Jian'an Luan Anubha Mahajan Satu Männistö Cameron D. Palmer Janina S. Ried Robert A. Scott Alena Stancáková Peter J. Wagner Ayse Demirkan Angela Döring Vilmundur Gudnason Douglas P. Kiel Brigitte Kühnel Massimo Mangino Barbara Mcknight Cristina Menni Jeffrey R. O'Connell Ben A. Oostra Alan R. Shuldiner Kijoung Song Liesbeth Vandenput Cornelia M. van Duijn Peter Vollenweider Charles C. White Michael Boehnke Yvonne Boettcher Richard S. Cooper Nita G. Forouhi Christian Gieger Harald Grallert Aroon Hingorani Torben Jørgensen Pekka Jousilahti Mika Kivimaki Meena Kumari Markku Laakso Claudia Langenberg Allan Linneberg Amy Luke Colin A. Mckenzie Aarno Palotie Oluf Pedersen Annette Peters Konstantin Strauch Bamidele O. Tayo Nicholas J. Wareham David A. Bennett Lars Bertram John Blangero Matthias Blüher Claude Bouchard Harry Campbell Nam H. Cho Steven R. Cummings Stefan A. Czerwinski Ilja Demuth Rahel Eckardt Johan G. Eriksson Luigi Ferrucci Oscar H. Franco Philippe Froguel Ron T. Gansevoort Torben Hansen Tamara B. Harris Nicholas Hastie Markku Heliövaara Albert Hofman Joanne M. Jordan Antti Jula Mika Kähönen Eero Kajantie Paul B. Knekt Seppo Koskinen Peter Kovacs Terho Lehtimäki Lars Lind Yongmei Liu Eric S. Orwoll Clive Osmond Markus Perola Louis Pérusse Olli T. Raitakari Tuomo Rankinen D. C. Rao Treva K. Rice Fernando Rivadeneira Igor Rudan Veikko Salomaa Thorkild I. A. Sørensen Michael Stumvoll Anke Tönjes Bradford Towne Gregory J. Tranah Angelo Tremblay André G. Uitterlinden Pim van der Harst Erkki Vartiainen Jorma S. Viikari Veronique Vitart Marie-Claude Vohl Henry Völzke Mark Walker Henri Wallaschofski Sarah Wild James F. Wilson Loïc Yengo D. Timothy Bishop Ingrid B. Borecki John C. Chambers L. Adrienne Cupples Abbas Dehghan Panos Deloukas Ghazaleh Fatemifar Caroline Fox Terrence S. Furey Lude Franke Jiali Han David J. Hunter Juha Karjalainen Fredrik Karpe Robert C. Kaplan Jaspal S. Kooner Mark I. McCarthy Joanne M. Murabito Andrew P. Morris Julia A. N. Bishop Kari E. North Claes Ohlsson Ken K. Ong Inga Prokopenko J. Brent Richards Eric E. Schadt Tim D. Spector Elisabeth Widén Cristen J. Willer Jian Yang Erik Ingelsson Karen L. Mohlke Joel N. Hirschhorn John Andrew Pospisilik M. Carola Zillikens Cecilia Lindgren Tuomas Oskari Kilpeläinen Ruth J. F. Loos
author_sort	Yingchang Lu
title	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_short	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_full	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_fullStr	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_full_unstemmed	New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
title_sort	new loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/dece01483ac84fdb93ab7a953a7205a9
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newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ollitraitakari newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT tuomorankinen newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT dcrao newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT trevakrice newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT fernandorivadeneira newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT igorrudan newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT veikkosalomaa newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT thorkildiasørensen newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT michaelstumvoll newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT anketonjes 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henryvolzke newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT markwalker newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT henriwallaschofski newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT sarahwild newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT jamesfwilson newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT loicyengo newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT dtimothybishop newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ingridbborecki newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT johncchambers newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ladriennecupples newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT abbasdehghan newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT panosdeloukas newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ghazalehfatemifar newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT carolinefox newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT terrencesfurey newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ludefranke newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT jialihan newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT davidjhunter newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT juhakarjalainen newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT fredrikkarpe newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT robertckaplan newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT jaspalskooner newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT markimccarthy newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT joannemmurabito newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT andrewpmorris newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT juliaanbishop newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT karienorth newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT claesohlsson newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT kenkong newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ingaprokopenko newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT jbrentrichards newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ericeschadt newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT timdspector newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT elisabethwiden newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT cristenjwiller newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT jianyang newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT erikingelsson newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT karenlmohlke newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT joelnhirschhorn newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT johnandrewpospisilik newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT mcarolazillikens newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT cecilialindgren newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT tuomasoskarikilpelainen newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk AT ruthjfloos newlociforbodyfatpercentagereveallinkbetweenadiposityandcardiometabolicdiseaserisk
_version_	1718386506040606720
spelling	oai:doaj.org-article:dece01483ac84fdb93ab7a953a7205a92021-12-02T15:35:40ZNew loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk10.1038/ncomms104952041-1723https://doaj.org/article/dece01483ac84fdb93ab7a953a7205a92016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10495https://doaj.org/toc/2041-1723A genome-wide association meta-analysis study here shows novel genetic loci to be associated to body fat percentage, and describes cross-phenotype association that further demonstrate a close relationship between adiposity and cardiovascular disease risk.Yingchang LuFelix R. DayStefan GustafssonMartin L. BuchkovichJianbo NaVeronique BatailleDiana L. CousminerZari DastaniAlexander W. DrongTõnu EskoDavid M. EvansMario FalchiMary F. FeitosaTeresa FerreiraÅsa K. HedmanRobin HaringPirro G. HysiMark M. IlesAnne E. JusticeStavroula KanoniVasiliki LagouRui LiXin LiAdam LockeChen LuReedik MägiJohn R. B. PerryTune H. PersQibin QiMarianna SannaEllen M. SchmidtWilliam R. ScottDmitry ShunginAlexander TeumerAnna A. E. VinkhuyzenRyan W. WalkerHarm-Jan WestraMingfeng ZhangWeihua ZhangJing Hua ZhaoZhihong ZhuUzma AfzalTarunveer Singh AhluwaliaStephan J. L. BakkerClaire BellisAmélie BonnefondKatja BorodulinAron S. BuchmanTommy CederholmAudrey C. ChohHyung Jin ChoiJoanne E. CurranLisette C. P. G. M. de GrootPhilip L. De JagerRosalie A. M. Dhonukshe-RuttenAnke W. EnnemanElodie EuryDaniel S. EvansTom ForsenNele FriedrichFrédéric FumeronMelissa E. GarciaSimone GärtnerBok-Ghee HanAki S. HavulinnaCaroline HaywardDena HernandezHans HillegeTill IttermannJack W. KentIvana KolcicTiina LaatikainenJari LahtiIrene Mateo LeachChristine G. LeeJong-Young LeeTian LiuYoufang LiuStéphane LobbensMarie LohLeo-Pekka LyytikäinenCarolina Medina-GomezKarl MichaëlssonMike A. NallsCarrie M. NielsonLaticia OozageerLaura PascoeLavinia PaternosterOzren PolašekSamuli RipattiMark A. SarzynskiChan Soo ShinNina Smolej NarančićDominik SpiraPriya SrikanthElisabeth Steinhagen-ThiessenYun Ju SungKarin M. A. SwartLeena TaittonenToshiko TanakaEmmi TikkanenNathalie van der VeldeNatasja M. van SchoorNiek VerweijAlan F. WrightLei YuJoseph M. ZmudaNiina EklundTerrence ForresterNiels GrarupAnne U. JacksonKati KristianssonTeemu KuulasmaaJohanna KuusistoPeter LichtnerJian'an LuanAnubha MahajanSatu MännistöCameron D. PalmerJanina S. RiedRobert A. ScottAlena StancákováPeter J. WagnerAyse DemirkanAngela DöringVilmundur GudnasonDouglas P. KielBrigitte KühnelMassimo ManginoBarbara McknightCristina MenniJeffrey R. O'ConnellBen A. OostraAlan R. ShuldinerKijoung SongLiesbeth VandenputCornelia M. van DuijnPeter VollenweiderCharles C. WhiteMichael BoehnkeYvonne BoettcherRichard S. CooperNita G. ForouhiChristian GiegerHarald GrallertAroon HingoraniTorben JørgensenPekka JousilahtiMika KivimakiMeena KumariMarkku LaaksoClaudia LangenbergAllan LinnebergAmy LukeColin A. MckenzieAarno PalotieOluf PedersenAnnette PetersKonstantin StrauchBamidele O. TayoNicholas J. WarehamDavid A. BennettLars BertramJohn BlangeroMatthias BlüherClaude BouchardHarry CampbellNam H. ChoSteven R. CummingsStefan A. CzerwinskiIlja DemuthRahel EckardtJohan G. ErikssonLuigi FerrucciOscar H. FrancoPhilippe FroguelRon T. GansevoortTorben HansenTamara B. HarrisNicholas HastieMarkku HeliövaaraAlbert HofmanJoanne M. JordanAntti JulaMika KähönenEero KajantiePaul B. KnektSeppo KoskinenPeter KovacsTerho LehtimäkiLars LindYongmei LiuEric S. OrwollClive OsmondMarkus PerolaLouis PérusseOlli T. RaitakariTuomo RankinenD. C. RaoTreva K. RiceFernando RivadeneiraIgor RudanVeikko SalomaaThorkild I. A. SørensenMichael StumvollAnke TönjesBradford TowneGregory J. TranahAngelo TremblayAndré G. UitterlindenPim van der HarstErkki VartiainenJorma S. ViikariVeronique VitartMarie-Claude VohlHenry VölzkeMark WalkerHenri WallaschofskiSarah WildJames F. WilsonLoïc YengoD. Timothy BishopIngrid B. BoreckiJohn C. ChambersL. Adrienne CupplesAbbas DehghanPanos DeloukasGhazaleh FatemifarCaroline FoxTerrence S. FureyLude FrankeJiali HanDavid J. HunterJuha KarjalainenFredrik KarpeRobert C. KaplanJaspal S. KoonerMark I. McCarthyJoanne M. MurabitoAndrew P. MorrisJulia A. N. BishopKari E. NorthClaes OhlssonKen K. OngInga ProkopenkoJ. Brent RichardsEric E. SchadtTim D. SpectorElisabeth WidénCristen J. WillerJian YangErik IngelssonKaren L. MohlkeJoel N. HirschhornJohn Andrew PospisilikM. Carola ZillikensCecilia LindgrenTuomas Oskari KilpeläinenRuth J. F. LoosNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

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