CYTOTOXIC AND CLASTOGENIC EVALUATION ON HUMAN LYMPHOCYTES OF A 5α, 8α-EPIDIOXYSTEROL

5α, 8α-epidioxysterol is obtained by photochemical oxidation of 7-dehydrocholesterol. This compound is analyzed using chromatographic and spectral techniques. This analysis identifies the compound as: 5α, 8α-epidioxy-cholesta-6-en-3β-ol. Cytotoxic and clastogenic effects of 5α, 8α-epidioxysterol by...

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Autores principales:	Andrés PAREJA, María E. MARQUEZ F., Alejandro MARTÍNEZ M.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	5α 8α-epidioxysterol cytotoxicity clastogenicity. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/ded9c21089ce479a9d74c0d29db9295d
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spelling	oai:doaj.org-article:ded9c21089ce479a9d74c0d29db9295d2021-11-19T04:17:12ZCYTOTOXIC AND CLASTOGENIC EVALUATION ON HUMAN LYMPHOCYTES OF A 5α, 8α-EPIDIOXYSTEROL0121-40042145-2660https://doaj.org/article/ded9c21089ce479a9d74c0d29db9295d2009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/800https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-26605α, 8α-epidioxysterol is obtained by photochemical oxidation of 7-dehydrocholesterol. This compound is analyzed using chromatographic and spectral techniques. This analysis identifies the compound as: 5α, 8α-epidioxy-cholesta-6-en-3β-ol. Cytotoxic and clastogenic effects of 5α, 8α-epidioxysterol by comet and exclusion assays with the tripan blue dye are evaluated. Three concentrations are used to determinate its effect on human lymphocytes from peripheral blood. No concentration shows clastogenic effect but the higher concentration exhibited cytotoxic effect. These results are interesting for this compound but it is necessary to do other in vitro and in vivo assays to evaluate the behavior on other cellular systems with the goal to determinate its bioactive potential. Andrés PAREJAAndrés PAREJAMaría E. MARQUEZ F.María E. MARQUEZ F.Alejandro MARTÍNEZ M.Alejandro MARTÍNEZ M.Universidad de Antioquiaarticle5α8α-epidioxysterolcytotoxicityclastogenicity.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 15, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	5α 8α-epidioxysterol cytotoxicity clastogenicity. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	5α 8α-epidioxysterol cytotoxicity clastogenicity. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Andrés PAREJA Andrés PAREJA María E. MARQUEZ F. María E. MARQUEZ F. Alejandro MARTÍNEZ M. Alejandro MARTÍNEZ M. CYTOTOXIC AND CLASTOGENIC EVALUATION ON HUMAN LYMPHOCYTES OF A 5α, 8α-EPIDIOXYSTEROL
description	5α, 8α-epidioxysterol is obtained by photochemical oxidation of 7-dehydrocholesterol. This compound is analyzed using chromatographic and spectral techniques. This analysis identifies the compound as: 5α, 8α-epidioxy-cholesta-6-en-3β-ol. Cytotoxic and clastogenic effects of 5α, 8α-epidioxysterol by comet and exclusion assays with the tripan blue dye are evaluated. Three concentrations are used to determinate its effect on human lymphocytes from peripheral blood. No concentration shows clastogenic effect but the higher concentration exhibited cytotoxic effect. These results are interesting for this compound but it is necessary to do other in vitro and in vivo assays to evaluate the behavior on other cellular systems with the goal to determinate its bioactive potential.
format	article
author	Andrés PAREJA Andrés PAREJA María E. MARQUEZ F. María E. MARQUEZ F. Alejandro MARTÍNEZ M. Alejandro MARTÍNEZ M.
author_facet	Andrés PAREJA Andrés PAREJA María E. MARQUEZ F. María E. MARQUEZ F. Alejandro MARTÍNEZ M. Alejandro MARTÍNEZ M.
author_sort	Andrés PAREJA
title	CYTOTOXIC AND CLASTOGENIC EVALUATION ON HUMAN LYMPHOCYTES OF A 5α, 8α-EPIDIOXYSTEROL
title_short	CYTOTOXIC AND CLASTOGENIC EVALUATION ON HUMAN LYMPHOCYTES OF A 5α, 8α-EPIDIOXYSTEROL
title_full	CYTOTOXIC AND CLASTOGENIC EVALUATION ON HUMAN LYMPHOCYTES OF A 5α, 8α-EPIDIOXYSTEROL
title_fullStr	CYTOTOXIC AND CLASTOGENIC EVALUATION ON HUMAN LYMPHOCYTES OF A 5α, 8α-EPIDIOXYSTEROL
title_full_unstemmed	CYTOTOXIC AND CLASTOGENIC EVALUATION ON HUMAN LYMPHOCYTES OF A 5α, 8α-EPIDIOXYSTEROL
title_sort	cytotoxic and clastogenic evaluation on human lymphocytes of a 5α, 8α-epidioxysterol
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/ded9c21089ce479a9d74c0d29db9295d
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CYTOTOXIC AND CLASTOGENIC EVALUATION ON HUMAN LYMPHOCYTES OF A 5α, 8α-EPIDIOXYSTEROL

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