The Staphylococcus aureus RNome and its commitment to virulence.

Staphylococcus aureus is a major human pathogen causing a wide spectrum of nosocomial and community-associated infections with high morbidity and mortality. S. aureus generates a large number of virulence factors whose timing and expression levels are precisely tuned by regulatory proteins and RNAs....

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Main Authors:	Brice Felden, François Vandenesch, Philippe Bouloc, Pascale Romby
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2011
Subjects:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/dedc2cf97476446a94a36e85b3af6196
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spelling	oai:doaj.org-article:dedc2cf97476446a94a36e85b3af61962021-11-18T06:03:32ZThe Staphylococcus aureus RNome and its commitment to virulence.1553-73661553-737410.1371/journal.ppat.1002006https://doaj.org/article/dedc2cf97476446a94a36e85b3af61962011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21423670/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Staphylococcus aureus is a major human pathogen causing a wide spectrum of nosocomial and community-associated infections with high morbidity and mortality. S. aureus generates a large number of virulence factors whose timing and expression levels are precisely tuned by regulatory proteins and RNAs. The aptitude of bacteria to use RNAs to rapidly modify gene expression, including virulence factors in response to stress or environmental changes, and to survive in a host is an evolving concept. Here, we focus on the recently inventoried S. aureus regulatory RNAs, with emphasis on those with identified functions, two of which are directly involved in pathogenicity.Brice FeldenFrançois VandeneschPhilippe BoulocPascale RombyPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 3, p e1002006 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Brice Felden François Vandenesch Philippe Bouloc Pascale Romby The Staphylococcus aureus RNome and its commitment to virulence.
description	Staphylococcus aureus is a major human pathogen causing a wide spectrum of nosocomial and community-associated infections with high morbidity and mortality. S. aureus generates a large number of virulence factors whose timing and expression levels are precisely tuned by regulatory proteins and RNAs. The aptitude of bacteria to use RNAs to rapidly modify gene expression, including virulence factors in response to stress or environmental changes, and to survive in a host is an evolving concept. Here, we focus on the recently inventoried S. aureus regulatory RNAs, with emphasis on those with identified functions, two of which are directly involved in pathogenicity.
format	article
author	Brice Felden François Vandenesch Philippe Bouloc Pascale Romby
author_facet	Brice Felden François Vandenesch Philippe Bouloc Pascale Romby
author_sort	Brice Felden
title	The Staphylococcus aureus RNome and its commitment to virulence.
title_short	The Staphylococcus aureus RNome and its commitment to virulence.
title_full	The Staphylococcus aureus RNome and its commitment to virulence.
title_fullStr	The Staphylococcus aureus RNome and its commitment to virulence.
title_full_unstemmed	The Staphylococcus aureus RNome and its commitment to virulence.
title_sort	staphylococcus aureus rnome and its commitment to virulence.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/dedc2cf97476446a94a36e85b3af6196
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The Staphylococcus aureus RNome and its commitment to virulence.

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