Natural and chemical compounds as protective agents against cardiac lipotoxicity

Cardiac lipotoxicity results from the deleterious effects of excess lipid deposition in cardiomyocytes. Lipotoxic cardiomyopathy involves cardiac lipid overload leading to changes in myocardial structure and function. Cardiac dysfunction has been associated with cardiac lipotoxicity through abnormal...

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Autores principales:	Fatemeh Yarmohammadi, A. Wallace Hayes, Gholamreza Karimi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	β-oxidation Cardiomyopathy Lipotoxicity Metabolism Mitochondria Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/dedfaf21cd7348379ab015c891db3a3e
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spelling	oai:doaj.org-article:dedfaf21cd7348379ab015c891db3a3e2021-11-14T04:30:33ZNatural and chemical compounds as protective agents against cardiac lipotoxicity0753-332210.1016/j.biopha.2021.112413https://doaj.org/article/dedfaf21cd7348379ab015c891db3a3e2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011999https://doaj.org/toc/0753-3322Cardiac lipotoxicity results from the deleterious effects of excess lipid deposition in cardiomyocytes. Lipotoxic cardiomyopathy involves cardiac lipid overload leading to changes in myocardial structure and function. Cardiac dysfunction has been associated with cardiac lipotoxicity through abnormal lipid metabolism. Lipid accumulation, especially saturated free fatty acids (SFFAs), in cardiac cells can cause cardiomyocyte distress and subsequent myocardial contractile dysfunction. Reducing the excess FAs supply or promoting FA storage is beneficial for cardiac function, especially under a lipotoxic condition.The protective effects of several compounds against lipotoxicity progression in the heart have been investigated. A variety of mechanisms has been suggested to prevent or treat cardiac lipotoxicity, including improvement of calcium homeostasis, lipid metabolism, and mitochondrial dysfunction. Known targets and signaling pathways involving a select group of chemicals that interfere with cardiac lipotoxicity pathogenesis are reviewed.Fatemeh YarmohammadiA. Wallace HayesGholamreza KarimiElsevierarticleβ-oxidationCardiomyopathyLipotoxicityMetabolismMitochondriaTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112413- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	β-oxidation Cardiomyopathy Lipotoxicity Metabolism Mitochondria Therapeutics. Pharmacology RM1-950
spellingShingle	β-oxidation Cardiomyopathy Lipotoxicity Metabolism Mitochondria Therapeutics. Pharmacology RM1-950 Fatemeh Yarmohammadi A. Wallace Hayes Gholamreza Karimi Natural and chemical compounds as protective agents against cardiac lipotoxicity
description	Cardiac lipotoxicity results from the deleterious effects of excess lipid deposition in cardiomyocytes. Lipotoxic cardiomyopathy involves cardiac lipid overload leading to changes in myocardial structure and function. Cardiac dysfunction has been associated with cardiac lipotoxicity through abnormal lipid metabolism. Lipid accumulation, especially saturated free fatty acids (SFFAs), in cardiac cells can cause cardiomyocyte distress and subsequent myocardial contractile dysfunction. Reducing the excess FAs supply or promoting FA storage is beneficial for cardiac function, especially under a lipotoxic condition.The protective effects of several compounds against lipotoxicity progression in the heart have been investigated. A variety of mechanisms has been suggested to prevent or treat cardiac lipotoxicity, including improvement of calcium homeostasis, lipid metabolism, and mitochondrial dysfunction. Known targets and signaling pathways involving a select group of chemicals that interfere with cardiac lipotoxicity pathogenesis are reviewed.
format	article
author	Fatemeh Yarmohammadi A. Wallace Hayes Gholamreza Karimi
author_facet	Fatemeh Yarmohammadi A. Wallace Hayes Gholamreza Karimi
author_sort	Fatemeh Yarmohammadi
title	Natural and chemical compounds as protective agents against cardiac lipotoxicity
title_short	Natural and chemical compounds as protective agents against cardiac lipotoxicity
title_full	Natural and chemical compounds as protective agents against cardiac lipotoxicity
title_fullStr	Natural and chemical compounds as protective agents against cardiac lipotoxicity
title_full_unstemmed	Natural and chemical compounds as protective agents against cardiac lipotoxicity
title_sort	natural and chemical compounds as protective agents against cardiac lipotoxicity
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/dedfaf21cd7348379ab015c891db3a3e
work_keys_str_mv	AT fatemehyarmohammadi naturalandchemicalcompoundsasprotectiveagentsagainstcardiaclipotoxicity AT awallacehayes naturalandchemicalcompoundsasprotectiveagentsagainstcardiaclipotoxicity AT gholamrezakarimi naturalandchemicalcompoundsasprotectiveagentsagainstcardiaclipotoxicity
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Natural and chemical compounds as protective agents against cardiac lipotoxicity

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