No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population

Abstract Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid–femoral pulse wave velocity (cfPW...

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Autores principales:	Wan-Ying Liang, Li-Hong Wang, Jian-Hang Wei, Qing-Lu Li, Qi-Yan Li, Quan Liang, Nai-Qing Hu, Li-Hua Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/dee0ebbd5cb84450976ba363537b42e6
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spelling	oai:doaj.org-article:dee0ebbd5cb84450976ba363537b42e62021-12-02T10:47:55ZNo significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population10.1038/s41598-021-82258-52045-2322https://doaj.org/article/dee0ebbd5cb84450976ba363537b42e62021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82258-5https://doaj.org/toc/2045-2322Abstract Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid–femoral pulse wave velocity (cfPWV) in a Chinese population. We invited all inhabitants aged ≥ 18 years in two Dali communities for participation. The SphygmoCor system was used to record radial arterial waveforms. Aortic waveforms were derived using a generalized transfer function. The central BP was assessed by calibrating the brachial BP, which was measured using an oscillometric device. The serum klotho concentration was measured using an enzyme-linked immunosorbent assay and logarithmically transformed. Of the 716 participants (mean age: 51.9 ± 12.6 years), 467 (65.2%) were women. The median serum klotho concentration was 381.8 pg/mL. The serum klotho concentration did not significantly differ between patients with and without hypertension (P > 0.05) and between those with and without arterial stiffness (cfPWV ≥ 10 m/s) (P > 0.05). After adjusting for confounders, the serum klotho concentration was not significantly associated with the peripheral or central BP (P > 0.05) and cfPWV (P > 0.05). Our data indicated that the serum klotho concentration was not associated with BP or cfPWV in the general Chinese population.Wan-Ying LiangLi-Hong WangJian-Hang WeiQing-Lu LiQi-Yan LiQuan LiangNai-Qing HuLi-Hua LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wan-Ying Liang Li-Hong Wang Jian-Hang Wei Qing-Lu Li Qi-Yan Li Quan Liang Nai-Qing Hu Li-Hua Li No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population
description	Abstract Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid–femoral pulse wave velocity (cfPWV) in a Chinese population. We invited all inhabitants aged ≥ 18 years in two Dali communities for participation. The SphygmoCor system was used to record radial arterial waveforms. Aortic waveforms were derived using a generalized transfer function. The central BP was assessed by calibrating the brachial BP, which was measured using an oscillometric device. The serum klotho concentration was measured using an enzyme-linked immunosorbent assay and logarithmically transformed. Of the 716 participants (mean age: 51.9 ± 12.6 years), 467 (65.2%) were women. The median serum klotho concentration was 381.8 pg/mL. The serum klotho concentration did not significantly differ between patients with and without hypertension (P > 0.05) and between those with and without arterial stiffness (cfPWV ≥ 10 m/s) (P > 0.05). After adjusting for confounders, the serum klotho concentration was not significantly associated with the peripheral or central BP (P > 0.05) and cfPWV (P > 0.05). Our data indicated that the serum klotho concentration was not associated with BP or cfPWV in the general Chinese population.
format	article
author	Wan-Ying Liang Li-Hong Wang Jian-Hang Wei Qing-Lu Li Qi-Yan Li Quan Liang Nai-Qing Hu Li-Hua Li
author_facet	Wan-Ying Liang Li-Hong Wang Jian-Hang Wei Qing-Lu Li Qi-Yan Li Quan Liang Nai-Qing Hu Li-Hua Li
author_sort	Wan-Ying Liang
title	No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population
title_short	No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population
title_full	No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population
title_fullStr	No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population
title_full_unstemmed	No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population
title_sort	no significant association of serum klotho concentration with blood pressure and pulse wave velocity in a chinese population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dee0ebbd5cb84450976ba363537b42e6
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No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population

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