Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation

Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation

ABSTRACT The Epstein-Barr virus (EBV) BILF1 gene encodes a constitutively active G protein-coupled receptor (GPCR) that downregulates major histocompatibility complex (MHC) class I and induces signaling-dependent tumorigenesis. Different BILF1 homologs display highly conserved extracellular loops (E...

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Bibliographic Details
Main Authors: Suzan Fares, Katja Spiess, Emma T. B. Olesen, Jianmin Zuo, Sarah Jackson, Thomas N. Kledal, Mark R. Wills, Mette M. Rosenkilde
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
EBV-BILF1
Epstein-Barr virus
GPCR
major histocompatibility complex
signaling
tumor immunology
Microbiology
QR1-502
Online Access:https://doaj.org/article/dee11feb9d2349f88db72d5cfb52eacb
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https://doaj.org/article/dee11feb9d2349f88db72d5cfb52eacb

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