Impact of HLA type, age and chronic viral infection on peripheral T-cell receptor sharing between unrelated individuals.

The human adaptive immune system must generate extraordinary diversity to be able to respond to all possible pathogens. The T-cell repertoire derives this high diversity through somatic recombination of the T-cell receptor (TCR) locus, a random process that results in repertoires that are largely pr...

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Autores principales: Sarah A Johnson, Spencer L Seale, Rachel M Gittelman, Julie A Rytlewski, Harlan S Robins, Paul A Fields
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/dee177985d1643a8a813d6a4f72cdbb8
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