Robust adaptive optics for localization microscopy deep in complex tissue

It is difficult to apply SMLM to complex biological tissues. Here the authors report REALM, Robust and Effective Adaptive Optics in Localisation Microscopy, to improve SMLM in tissue and use this to resolve the organisation of spectrin in the axon initial segment in brain tissue.

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Autores principales: Marijn E. Siemons, Naomi A. K. Hanemaaijer, Maarten H. P. Kole, Lukas C. Kapitein
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/dee4cf76855b40cbb4c28ab779681f9f
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spelling oai:doaj.org-article:dee4cf76855b40cbb4c28ab779681f9f2021-12-02T15:02:50ZRobust adaptive optics for localization microscopy deep in complex tissue10.1038/s41467-021-23647-22041-1723https://doaj.org/article/dee4cf76855b40cbb4c28ab779681f9f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23647-2https://doaj.org/toc/2041-1723It is difficult to apply SMLM to complex biological tissues. Here the authors report REALM, Robust and Effective Adaptive Optics in Localisation Microscopy, to improve SMLM in tissue and use this to resolve the organisation of spectrin in the axon initial segment in brain tissue.Marijn E. SiemonsNaomi A. K. HanemaaijerMaarten H. P. KoleLukas C. KapiteinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marijn E. Siemons
Naomi A. K. Hanemaaijer
Maarten H. P. Kole
Lukas C. Kapitein
Robust adaptive optics for localization microscopy deep in complex tissue
description It is difficult to apply SMLM to complex biological tissues. Here the authors report REALM, Robust and Effective Adaptive Optics in Localisation Microscopy, to improve SMLM in tissue and use this to resolve the organisation of spectrin in the axon initial segment in brain tissue.
format article
author Marijn E. Siemons
Naomi A. K. Hanemaaijer
Maarten H. P. Kole
Lukas C. Kapitein
author_facet Marijn E. Siemons
Naomi A. K. Hanemaaijer
Maarten H. P. Kole
Lukas C. Kapitein
author_sort Marijn E. Siemons
title Robust adaptive optics for localization microscopy deep in complex tissue
title_short Robust adaptive optics for localization microscopy deep in complex tissue
title_full Robust adaptive optics for localization microscopy deep in complex tissue
title_fullStr Robust adaptive optics for localization microscopy deep in complex tissue
title_full_unstemmed Robust adaptive optics for localization microscopy deep in complex tissue
title_sort robust adaptive optics for localization microscopy deep in complex tissue
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/dee4cf76855b40cbb4c28ab779681f9f
work_keys_str_mv AT marijnesiemons robustadaptiveopticsforlocalizationmicroscopydeepincomplextissue
AT naomiakhanemaaijer robustadaptiveopticsforlocalizationmicroscopydeepincomplextissue
AT maartenhpkole robustadaptiveopticsforlocalizationmicroscopydeepincomplextissue
AT lukasckapitein robustadaptiveopticsforlocalizationmicroscopydeepincomplextissue
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