Robust adaptive optics for localization microscopy deep in complex tissue

It is difficult to apply SMLM to complex biological tissues. Here the authors report REALM, Robust and Effective Adaptive Optics in Localisation Microscopy, to improve SMLM in tissue and use this to resolve the organisation of spectrin in the axon initial segment in brain tissue.

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Main Authors:	Marijn E. Siemons, Naomi A. K. Hanemaaijer, Maarten H. P. Kole, Lukas C. Kapitein
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/dee4cf76855b40cbb4c28ab779681f9f
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spelling	oai:doaj.org-article:dee4cf76855b40cbb4c28ab779681f9f2021-12-02T15:02:50ZRobust adaptive optics for localization microscopy deep in complex tissue10.1038/s41467-021-23647-22041-1723https://doaj.org/article/dee4cf76855b40cbb4c28ab779681f9f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23647-2https://doaj.org/toc/2041-1723It is difficult to apply SMLM to complex biological tissues. Here the authors report REALM, Robust and Effective Adaptive Optics in Localisation Microscopy, to improve SMLM in tissue and use this to resolve the organisation of spectrin in the axon initial segment in brain tissue.Marijn E. SiemonsNaomi A. K. HanemaaijerMaarten H. P. KoleLukas C. KapiteinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marijn E. Siemons Naomi A. K. Hanemaaijer Maarten H. P. Kole Lukas C. Kapitein Robust adaptive optics for localization microscopy deep in complex tissue
description	It is difficult to apply SMLM to complex biological tissues. Here the authors report REALM, Robust and Effective Adaptive Optics in Localisation Microscopy, to improve SMLM in tissue and use this to resolve the organisation of spectrin in the axon initial segment in brain tissue.
format	article
author	Marijn E. Siemons Naomi A. K. Hanemaaijer Maarten H. P. Kole Lukas C. Kapitein
author_facet	Marijn E. Siemons Naomi A. K. Hanemaaijer Maarten H. P. Kole Lukas C. Kapitein
author_sort	Marijn E. Siemons
title	Robust adaptive optics for localization microscopy deep in complex tissue
title_short	Robust adaptive optics for localization microscopy deep in complex tissue
title_full	Robust adaptive optics for localization microscopy deep in complex tissue
title_fullStr	Robust adaptive optics for localization microscopy deep in complex tissue
title_full_unstemmed	Robust adaptive optics for localization microscopy deep in complex tissue
title_sort	robust adaptive optics for localization microscopy deep in complex tissue
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dee4cf76855b40cbb4c28ab779681f9f
work_keys_str_mv	AT marijnesiemons robustadaptiveopticsforlocalizationmicroscopydeepincomplextissue AT naomiakhanemaaijer robustadaptiveopticsforlocalizationmicroscopydeepincomplextissue AT maartenhpkole robustadaptiveopticsforlocalizationmicroscopydeepincomplextissue AT lukasckapitein robustadaptiveopticsforlocalizationmicroscopydeepincomplextissue
_version_	1718389107762135040

Robust adaptive optics for localization microscopy deep in complex tissue

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