Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells

Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and not rescued by inhibition of the ensuing integr...

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Autores principales:	Gustavo Della-Flora Nunes, Emma R. Wilson, Leandro N. Marziali, Edward Hurley, Nicholas Silvestri, Bin He, Bert W. O’Malley, Bogdan Beirowski, Yannick Poitelon, Lawrence Wrabetz, M. Laura Feltri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dee61ba939654c5b97e3ebabed37e14e
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spelling	oai:doaj.org-article:dee61ba939654c5b97e3ebabed37e14e2021-12-02T18:24:57ZProhibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells10.1038/s41467-021-23552-82041-1723https://doaj.org/article/dee61ba939654c5b97e3ebabed37e14e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23552-8https://doaj.org/toc/2041-1723Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and not rescued by inhibition of the ensuing integrated stress response.Gustavo Della-Flora NunesEmma R. WilsonLeandro N. MarzialiEdward HurleyNicholas SilvestriBin HeBert W. O’MalleyBogdan BeirowskiYannick PoitelonLawrence WrabetzM. Laura FeltriNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gustavo Della-Flora Nunes Emma R. Wilson Leandro N. Marziali Edward Hurley Nicholas Silvestri Bin He Bert W. O’Malley Bogdan Beirowski Yannick Poitelon Lawrence Wrabetz M. Laura Feltri Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
description	Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and not rescued by inhibition of the ensuing integrated stress response.
format	article
author	Gustavo Della-Flora Nunes Emma R. Wilson Leandro N. Marziali Edward Hurley Nicholas Silvestri Bin He Bert W. O’Malley Bogdan Beirowski Yannick Poitelon Lawrence Wrabetz M. Laura Feltri
author_facet	Gustavo Della-Flora Nunes Emma R. Wilson Leandro N. Marziali Edward Hurley Nicholas Silvestri Bin He Bert W. O’Malley Bogdan Beirowski Yannick Poitelon Lawrence Wrabetz M. Laura Feltri
author_sort	Gustavo Della-Flora Nunes
title	Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
title_short	Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
title_full	Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
title_fullStr	Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
title_full_unstemmed	Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
title_sort	prohibitin 1 is essential to preserve mitochondria and myelin integrity in schwann cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dee61ba939654c5b97e3ebabed37e14e
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Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells

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