Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells

Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells

Prohibitin 2 can localize to the axon-Schwann-cell interface and is required for myelin formation. Here, the authors show that deletion of prohibitin 1 in Schwann cells instead triggers severe myelin loss likely caused by mitochondrial dysfunction, and not rescued by inhibition of the ensuing integr...

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Autores principales: Gustavo Della-Flora Nunes, Emma R. Wilson, Leandro N. Marziali, Edward Hurley, Nicholas Silvestri, Bin He, Bert W. O’Malley, Bogdan Beirowski, Yannick Poitelon, Lawrence Wrabetz, M. Laura Feltri
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/dee61ba939654c5b97e3ebabed37e14e
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