Altered brain responses to specific negative emotions in schizophrenia

Deficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases are poorly understood. Previous research, mainly focused on emotional face processing and emotion recognition deficits, has shown controverted results. Furthermore, the use of faces has been questione...

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Autores principales:	Maria Angeles Garcia-Leon, Paola Fuentes-Claramonte, Alicia Valiente-Gómez, Carmen Natividad, Pilar Salgado-Pineda, Jesús J. Gomar, Amalia Guerrero-Pedraza, Francisco Portillo, Jordi Ortiz-Gil, Silvia Alonso-Lana, Teresa Maristany, Joaquim Raduà, Raymond Salvador, Salvador Sarró, Edith Pomarol-Clotet
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Schizophrenia IAPS Scenic stimuli fMRI Emotions Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/dee99548348946b7b15b4485e226cc72
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id	oai:doaj.org-article:dee99548348946b7b15b4485e226cc72
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spelling	oai:doaj.org-article:dee99548348946b7b15b4485e226cc722021-12-02T05:01:30ZAltered brain responses to specific negative emotions in schizophrenia2213-158210.1016/j.nicl.2021.102894https://doaj.org/article/dee99548348946b7b15b4485e226cc722021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003387https://doaj.org/toc/2213-1582Deficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases are poorly understood. Previous research, mainly focused on emotional face processing and emotion recognition deficits, has shown controverted results. Furthermore, the use of faces has been questioned for not entailing an appropriate stimulus to study emotional processing. This highlights the importance of investigating emotional processing abnormalities using evocative stimuli. For the first time, we have studied the brain responses to scenic stimuli in patients with schizophrenia. We selected scenes from the IAPS that elicit fear, disgust, happiness, and sadness. Twenty-six patients with schizophrenia and thirty age-, sex- and premorbid IQ-matched healthy controls were included. Behavioral task results show that patients tended to misclassify disgust and sadness as fear. Brain responses in patients were different from controls in images eliciting disgust and fear. In response to disgust images, patients hyperactivated the right temporal cortex, which was not activated by the controls. With fear images, hyperactivation was observed in brain regions involved in fear processing, including midline regions from the medial frontal cortex to the anterior cingulate cortex, the superior frontal gyrus, inferior and superior temporal cortex, and visual areas. These results suggest that schizophrenia is characterized by hyper-responsivity to stimuli evoking high-arousal, negative emotions, and a bias towards fear in emotion recognition.Maria Angeles Garcia-LeonPaola Fuentes-ClaramonteAlicia Valiente-GómezCarmen NatividadPilar Salgado-PinedaJesús J. GomarAmalia Guerrero-PedrazaFrancisco PortilloJordi Ortiz-GilSilvia Alonso-LanaTeresa MaristanyJoaquim RaduàRaymond SalvadorSalvador SarróEdith Pomarol-ClotetElsevierarticleSchizophreniaIAPSScenic stimulifMRIEmotionsComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102894- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schizophrenia IAPS Scenic stimuli fMRI Emotions Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Schizophrenia IAPS Scenic stimuli fMRI Emotions Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Maria Angeles Garcia-Leon Paola Fuentes-Claramonte Alicia Valiente-Gómez Carmen Natividad Pilar Salgado-Pineda Jesús J. Gomar Amalia Guerrero-Pedraza Francisco Portillo Jordi Ortiz-Gil Silvia Alonso-Lana Teresa Maristany Joaquim Raduà Raymond Salvador Salvador Sarró Edith Pomarol-Clotet Altered brain responses to specific negative emotions in schizophrenia
description	Deficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases are poorly understood. Previous research, mainly focused on emotional face processing and emotion recognition deficits, has shown controverted results. Furthermore, the use of faces has been questioned for not entailing an appropriate stimulus to study emotional processing. This highlights the importance of investigating emotional processing abnormalities using evocative stimuli. For the first time, we have studied the brain responses to scenic stimuli in patients with schizophrenia. We selected scenes from the IAPS that elicit fear, disgust, happiness, and sadness. Twenty-six patients with schizophrenia and thirty age-, sex- and premorbid IQ-matched healthy controls were included. Behavioral task results show that patients tended to misclassify disgust and sadness as fear. Brain responses in patients were different from controls in images eliciting disgust and fear. In response to disgust images, patients hyperactivated the right temporal cortex, which was not activated by the controls. With fear images, hyperactivation was observed in brain regions involved in fear processing, including midline regions from the medial frontal cortex to the anterior cingulate cortex, the superior frontal gyrus, inferior and superior temporal cortex, and visual areas. These results suggest that schizophrenia is characterized by hyper-responsivity to stimuli evoking high-arousal, negative emotions, and a bias towards fear in emotion recognition.
format	article
author	Maria Angeles Garcia-Leon Paola Fuentes-Claramonte Alicia Valiente-Gómez Carmen Natividad Pilar Salgado-Pineda Jesús J. Gomar Amalia Guerrero-Pedraza Francisco Portillo Jordi Ortiz-Gil Silvia Alonso-Lana Teresa Maristany Joaquim Raduà Raymond Salvador Salvador Sarró Edith Pomarol-Clotet
author_facet	Maria Angeles Garcia-Leon Paola Fuentes-Claramonte Alicia Valiente-Gómez Carmen Natividad Pilar Salgado-Pineda Jesús J. Gomar Amalia Guerrero-Pedraza Francisco Portillo Jordi Ortiz-Gil Silvia Alonso-Lana Teresa Maristany Joaquim Raduà Raymond Salvador Salvador Sarró Edith Pomarol-Clotet
author_sort	Maria Angeles Garcia-Leon
title	Altered brain responses to specific negative emotions in schizophrenia
title_short	Altered brain responses to specific negative emotions in schizophrenia
title_full	Altered brain responses to specific negative emotions in schizophrenia
title_fullStr	Altered brain responses to specific negative emotions in schizophrenia
title_full_unstemmed	Altered brain responses to specific negative emotions in schizophrenia
title_sort	altered brain responses to specific negative emotions in schizophrenia
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/dee99548348946b7b15b4485e226cc72
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_version_	1718400860431581184

Altered brain responses to specific negative emotions in schizophrenia

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