Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes

Polycomb repressive complexes (PRC1 and PRC2) repress genes that are crucial for development via epigenetic modifications; however, their role in differentiation is not well known. Here the authors reveal that a PCGF1-containing PRC1 variant facilitates exit from pluripotency by downregulating targe...

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Autores principales:	Hiroki Sugishita, Takashi Kondo, Shinsuke Ito, Manabu Nakayama, Nayuta Yakushiji-Kaminatsui, Eiryo Kawakami, Yoko Koseki, Yasuhide Ohinata, Jafar Sharif, Mio Harachi, Neil P. Blackledge, Robert J. Klose, Haruhiko Koseki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/dee9c656f1d944dab8edc3fb703eee1f
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spelling	oai:doaj.org-article:dee9c656f1d944dab8edc3fb703eee1f2021-12-02T14:55:14ZVariant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes10.1038/s41467-021-24894-z2041-1723https://doaj.org/article/dee9c656f1d944dab8edc3fb703eee1f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24894-zhttps://doaj.org/toc/2041-1723Polycomb repressive complexes (PRC1 and PRC2) repress genes that are crucial for development via epigenetic modifications; however, their role in differentiation is not well known. Here the authors reveal that a PCGF1-containing PRC1 variant facilitates exit from pluripotency by downregulating target genes and recruiting PRC2.Hiroki SugishitaTakashi KondoShinsuke ItoManabu NakayamaNayuta Yakushiji-KaminatsuiEiryo KawakamiYoko KosekiYasuhide OhinataJafar SharifMio HarachiNeil P. BlackledgeRobert J. KloseHaruhiko KosekiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroki Sugishita Takashi Kondo Shinsuke Ito Manabu Nakayama Nayuta Yakushiji-Kaminatsui Eiryo Kawakami Yoko Koseki Yasuhide Ohinata Jafar Sharif Mio Harachi Neil P. Blackledge Robert J. Klose Haruhiko Koseki Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
description	Polycomb repressive complexes (PRC1 and PRC2) repress genes that are crucial for development via epigenetic modifications; however, their role in differentiation is not well known. Here the authors reveal that a PCGF1-containing PRC1 variant facilitates exit from pluripotency by downregulating target genes and recruiting PRC2.
format	article
author	Hiroki Sugishita Takashi Kondo Shinsuke Ito Manabu Nakayama Nayuta Yakushiji-Kaminatsui Eiryo Kawakami Yoko Koseki Yasuhide Ohinata Jafar Sharif Mio Harachi Neil P. Blackledge Robert J. Klose Haruhiko Koseki
author_facet	Hiroki Sugishita Takashi Kondo Shinsuke Ito Manabu Nakayama Nayuta Yakushiji-Kaminatsui Eiryo Kawakami Yoko Koseki Yasuhide Ohinata Jafar Sharif Mio Harachi Neil P. Blackledge Robert J. Klose Haruhiko Koseki
author_sort	Hiroki Sugishita
title	Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
title_short	Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
title_full	Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
title_fullStr	Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
title_full_unstemmed	Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
title_sort	variant pcgf1-prc1 links prc2 recruitment with differentiation-associated transcriptional inactivation at target genes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/dee9c656f1d944dab8edc3fb703eee1f
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Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes

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