Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways

Abstract E-cigarettes are heavily advertised as healthier alternative to common tobacco cigarettes, leading more and more women to switch from regular cigarettes to ENDS (electronic nicotine delivery system) during pregnancy. While the noxious consequences of tobacco smoking during pregnancy on the...

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Autores principales:	Natalia El-Merhie, Arne Krüger, Karin Uliczka, Stephanie Papenmeier, Thomas Roeder, Klaus F. Rabe, Christina Wagner, Hanna Angstmann, Susanne Krauss-Etschmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/def14393109e453ba1572275ef6f0ecb
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spelling	oai:doaj.org-article:def14393109e453ba1572275ef6f0ecb2021-12-02T15:54:06ZSex dependent effect of maternal e-nicotine on F1 Drosophila development and airways10.1038/s41598-021-81607-82045-2322https://doaj.org/article/def14393109e453ba1572275ef6f0ecb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81607-8https://doaj.org/toc/2045-2322Abstract E-cigarettes are heavily advertised as healthier alternative to common tobacco cigarettes, leading more and more women to switch from regular cigarettes to ENDS (electronic nicotine delivery system) during pregnancy. While the noxious consequences of tobacco smoking during pregnancy on the offspring health are well-described, information on the long-term consequences due to maternal use of e-cigarettes do not exist so far. Therefore, we aimed to investigate how maternal e-nicotine influences offspring development from earliest life until adulthood. To this end, virgin female Drosophila melanogaster flies were exposed to nicotine vapor (8 µg nicotine) once per hour for a total of eight times. Following the last exposure, e-nicotine or sham exposed females were mated with non-exposed males. The F1-generation was then analyzed for viability, growth and airway structure. We demonstrate that maternal exposure to e-nicotine not only leads to reduced maternal fertility, but also negatively affects size and weight, as well as tracheal development of the F1-generation, lasting from embryonic stage until adulthood. These results not only underline the need for studies investigating the effects of maternal vaping on offspring health, but also propose our established model for analyzing molecular mechanisms and signaling pathways mediating these intergenerational changes.Natalia El-MerhieArne KrügerKarin UliczkaStephanie PapenmeierThomas RoederKlaus F. RabeChristina WagnerHanna AngstmannSusanne Krauss-EtschmannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalia El-Merhie Arne Krüger Karin Uliczka Stephanie Papenmeier Thomas Roeder Klaus F. Rabe Christina Wagner Hanna Angstmann Susanne Krauss-Etschmann Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways
description	Abstract E-cigarettes are heavily advertised as healthier alternative to common tobacco cigarettes, leading more and more women to switch from regular cigarettes to ENDS (electronic nicotine delivery system) during pregnancy. While the noxious consequences of tobacco smoking during pregnancy on the offspring health are well-described, information on the long-term consequences due to maternal use of e-cigarettes do not exist so far. Therefore, we aimed to investigate how maternal e-nicotine influences offspring development from earliest life until adulthood. To this end, virgin female Drosophila melanogaster flies were exposed to nicotine vapor (8 µg nicotine) once per hour for a total of eight times. Following the last exposure, e-nicotine or sham exposed females were mated with non-exposed males. The F1-generation was then analyzed for viability, growth and airway structure. We demonstrate that maternal exposure to e-nicotine not only leads to reduced maternal fertility, but also negatively affects size and weight, as well as tracheal development of the F1-generation, lasting from embryonic stage until adulthood. These results not only underline the need for studies investigating the effects of maternal vaping on offspring health, but also propose our established model for analyzing molecular mechanisms and signaling pathways mediating these intergenerational changes.
format	article
author	Natalia El-Merhie Arne Krüger Karin Uliczka Stephanie Papenmeier Thomas Roeder Klaus F. Rabe Christina Wagner Hanna Angstmann Susanne Krauss-Etschmann
author_facet	Natalia El-Merhie Arne Krüger Karin Uliczka Stephanie Papenmeier Thomas Roeder Klaus F. Rabe Christina Wagner Hanna Angstmann Susanne Krauss-Etschmann
author_sort	Natalia El-Merhie
title	Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways
title_short	Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways
title_full	Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways
title_fullStr	Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways
title_full_unstemmed	Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways
title_sort	sex dependent effect of maternal e-nicotine on f1 drosophila development and airways
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/def14393109e453ba1572275ef6f0ecb
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Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways

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