A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

Bioconjugation is a promising process to manufacture conjugate vaccines, but currently employed enzymes cannot generate the full spectrum of bacterial glycoproteins. Here, the authors use an O-linking oligosaccharyltransferase to generate a polyvalent pneumococcal bioconjugate vaccine with polysacch...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christian M. Harding, Mohamed A. Nasr, Nichollas E. Scott, Guillaume Goyette-Desjardins, Harald Nothaft, Anne E. Mayer, Sthefany M. Chavez, Jeremy P. Huynh, Rachel L. Kinsella, Christine M. Szymanski, Christina L. Stallings, Mariela Segura, Mario F. Feldman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/def4f3d9176a44dbb8129ca597b1866c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:def4f3d9176a44dbb8129ca597b1866c
record_format	dspace
spelling	oai:doaj.org-article:def4f3d9176a44dbb8129ca597b1866c2021-12-02T16:58:27ZA platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host10.1038/s41467-019-08869-92041-1723https://doaj.org/article/def4f3d9176a44dbb8129ca597b1866c2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08869-9https://doaj.org/toc/2041-1723Bioconjugation is a promising process to manufacture conjugate vaccines, but currently employed enzymes cannot generate the full spectrum of bacterial glycoproteins. Here, the authors use an O-linking oligosaccharyltransferase to generate a polyvalent pneumococcal bioconjugate vaccine with polysaccharides containing glucose at their reducing end.Christian M. HardingMohamed A. NasrNichollas E. ScottGuillaume Goyette-DesjardinsHarald NothaftAnne E. MayerSthefany M. ChavezJeremy P. HuynhRachel L. KinsellaChristine M. SzymanskiChristina L. StallingsMariela SeguraMario F. FeldmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christian M. Harding Mohamed A. Nasr Nichollas E. Scott Guillaume Goyette-Desjardins Harald Nothaft Anne E. Mayer Sthefany M. Chavez Jeremy P. Huynh Rachel L. Kinsella Christine M. Szymanski Christina L. Stallings Mariela Segura Mario F. Feldman A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host
description	Bioconjugation is a promising process to manufacture conjugate vaccines, but currently employed enzymes cannot generate the full spectrum of bacterial glycoproteins. Here, the authors use an O-linking oligosaccharyltransferase to generate a polyvalent pneumococcal bioconjugate vaccine with polysaccharides containing glucose at their reducing end.
format	article
author	Christian M. Harding Mohamed A. Nasr Nichollas E. Scott Guillaume Goyette-Desjardins Harald Nothaft Anne E. Mayer Sthefany M. Chavez Jeremy P. Huynh Rachel L. Kinsella Christine M. Szymanski Christina L. Stallings Mariela Segura Mario F. Feldman
author_facet	Christian M. Harding Mohamed A. Nasr Nichollas E. Scott Guillaume Goyette-Desjardins Harald Nothaft Anne E. Mayer Sthefany M. Chavez Jeremy P. Huynh Rachel L. Kinsella Christine M. Szymanski Christina L. Stallings Mariela Segura Mario F. Feldman
author_sort	Christian M. Harding
title	A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host
title_short	A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host
title_full	A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host
title_fullStr	A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host
title_full_unstemmed	A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host
title_sort	platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using e. coli as a host
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/def4f3d9176a44dbb8129ca597b1866c
work_keys_str_mv	AT christianmharding aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT mohamedanasr aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT nichollasescott aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT guillaumegoyettedesjardins aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT haraldnothaft aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT anneemayer aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT sthefanymchavez aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT jeremyphuynh aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT rachellkinsella aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT christinemszymanski aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT christinalstallings aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT marielasegura aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT marioffeldman aplatformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT christianmharding platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT mohamedanasr platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT nichollasescott platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT guillaumegoyettedesjardins platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT haraldnothaft platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT anneemayer platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT sthefanymchavez platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT jeremyphuynh platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT rachellkinsella platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT christinemszymanski platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT christinalstallings platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT marielasegura platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost AT marioffeldman platformforglycoengineeringapolyvalentpneumococcalbioconjugatevaccineusingecoliasahost
_version_	1718382299602485248

A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

Ejemplares similares